Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood

VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo‐Controlled, Double‐Blind, Crossover Study

“…In spite of important progress made in the last several years in understanding its causes and mechanisms, treatment options are lagging behind. In fact, a recent large meta‐analysis (2) of available evidence on the efficacy of pharmacological treatment of IBS in children concluded that there was “weak evidence of benefit on medication in children with recurrent abdominal pain. The lack of clear evidence of effectiveness for any of the recommended drugs suggests that there is little reason for their use outside of clinical trials.” The same authors reached essentially identical conclusions when reviewing evidence of efficacy for dietetic interventions (3).…”

VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo‐Controlled, Double‐Blind, Crossover Study

“…In spite of important progress made in the last several years in understanding its causes and mechanisms, treatment options are lagging behind. In fact, a recent large meta‐analysis (2) of available evidence on the efficacy of pharmacological treatment of IBS in children concluded that there was “weak evidence of benefit on medication in children with recurrent abdominal pain. The lack of clear evidence of effectiveness for any of the recommended drugs suggests that there is little reason for their use outside of clinical trials.” The same authors reached essentially identical conclusions when reviewing evidence of efficacy for dietetic interventions (3).…”

Pharmacologic Management of Acute Pain in Children

“…A medical librarian developed database-specific search strategies without language restrictions and searched the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), Embase, CINAHL, Web of Science, and Scopus from inception until October 3, 2023 (eMethods 1 in Supplement 1). We reviewed the reference lists of eligible trials and related reviews to identify additional eligible RCTs …”

“…17 A medical librarian developed database-specific search strategies without language restrictions and searched the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), Embase, CINAHL, Web of Science, and Scopus from inception until October 3, 2023 (eMethods 1 in Supplement 1). We reviewed the reference lists of eligible trials and related reviews [18][19][20] to identify additional eligible RCTs. 21,22 Pairs of reviewers independently screened the titles and abstracts of identified studies and assessed the full-text articles of all potentially eligible studies, resolving discrepancies through discussion.…”

Features of drug therapy for functional gastrointestinal disorders in children of preschool and primary school age

“…Доказана эффективность препарата при лечении синдрома раздраженного кишечника [38][39][40][41], функциональной диспепсии [42,43], функциональных запоров [44,45], билиарных дисфункций [29,46] и сочетанных функциональных заболеваний (т. н. «синдрома перекреста») [30,47,48].…”

“…Согласно многочисленным обзорам [48,[60][61][62], применение тримебутина у детей с СРК и абдоминальной болью высокоэффективно (имеет уровень доказательности В) и безопасно. В исследовании [53] был показан достоверный положительный эффект применения тримебутина у детей с функциональными нарушениями Гастроэнтерология моторики желудочно-кишечного тракта.…”

VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo‐Controlled, Double‐Blind, Crossover Study

“…In spite of important progress made in the last several years in understanding its causes and mechanisms, treatment options are lagging behind. In fact, a recent large meta‐analysis (2) of available evidence on the efficacy of pharmacological treatment of IBS in children concluded that there was “weak evidence of benefit on medication in children with recurrent abdominal pain. The lack of clear evidence of effectiveness for any of the recommended drugs suggests that there is little reason for their use outside of clinical trials.” The same authors reached essentially identical conclusions when reviewing evidence of efficacy for dietetic interventions (3).…”

Pharmacologic Management of Acute Pain in Children

“…A medical librarian developed database-specific search strategies without language restrictions and searched the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), Embase, CINAHL, Web of Science, and Scopus from inception until October 3, 2023 (eMethods 1 in Supplement 1). We reviewed the reference lists of eligible trials and related reviews to identify additional eligible RCTs …”

“…17 A medical librarian developed database-specific search strategies without language restrictions and searched the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), Embase, CINAHL, Web of Science, and Scopus from inception until October 3, 2023 (eMethods 1 in Supplement 1). We reviewed the reference lists of eligible trials and related reviews [18][19][20] to identify additional eligible RCTs. 21,22 Pairs of reviewers independently screened the titles and abstracts of identified studies and assessed the full-text articles of all potentially eligible studies, resolving discrepancies through discussion.…”

Features of drug therapy for functional gastrointestinal disorders in children of preschool and primary school age

“…Доказана эффективность препарата при лечении синдрома раздраженного кишечника [38][39][40][41], функциональной диспепсии [42,43], функциональных запоров [44,45], билиарных дисфункций [29,46] и сочетанных функциональных заболеваний (т. н. «синдрома перекреста») [30,47,48].…”

“…Согласно многочисленным обзорам [48,[60][61][62], применение тримебутина у детей с СРК и абдоминальной болью высокоэффективно (имеет уровень доказательности В) и безопасно. В исследовании [53] был показан достоверный положительный эффект применения тримебутина у детей с функциональными нарушениями Гастроэнтерология моторики желудочно-кишечного тракта.…”

VSL#3 Improves Symptoms in Children With Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo‐Controlled, Double‐Blind, Crossover Study

“…In spite of important progress made in the last several years in understanding its causes and mechanisms, treatment options are lagging behind. In fact, a recent large meta‐analysis (2) of available evidence on the efficacy of pharmacological treatment of IBS in children concluded that there was “weak evidence of benefit on medication in children with recurrent abdominal pain. The lack of clear evidence of effectiveness for any of the recommended drugs suggests that there is little reason for their use outside of clinical trials.” The same authors reached essentially identical conclusions when reviewing evidence of efficacy for dietetic interventions (3).…”

Pharmacologic Management of Acute Pain in Children

“…A medical librarian developed database-specific search strategies without language restrictions and searched the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), Embase, CINAHL, Web of Science, and Scopus from inception until October 3, 2023 (eMethods 1 in Supplement 1). We reviewed the reference lists of eligible trials and related reviews to identify additional eligible RCTs …”

“…17 A medical librarian developed database-specific search strategies without language restrictions and searched the Cochrane Central Register of Controlled Trials (CENTRAL), Medline (via Ovid), Embase, CINAHL, Web of Science, and Scopus from inception until October 3, 2023 (eMethods 1 in Supplement 1). We reviewed the reference lists of eligible trials and related reviews [18][19][20] to identify additional eligible RCTs. 21,22 Pairs of reviewers independently screened the titles and abstracts of identified studies and assessed the full-text articles of all potentially eligible studies, resolving discrepancies through discussion.…”

Features of drug therapy for functional gastrointestinal disorders in children of preschool and primary school age

“…Доказана эффективность препарата при лечении синдрома раздраженного кишечника [38][39][40][41], функциональной диспепсии [42,43], функциональных запоров [44,45], билиарных дисфункций [29,46] и сочетанных функциональных заболеваний (т. н. «синдрома перекреста») [30,47,48].…”

“…Согласно многочисленным обзорам [48,[60][61][62], применение тримебутина у детей с СРК и абдоминальной болью высокоэффективно (имеет уровень доказательности В) и безопасно. В исследовании [53] был показан достоверный положительный эффект применения тримебутина у детей с функциональными нарушениями Гастроэнтерология моторики желудочно-кишечного тракта.…”