1997
DOI: 10.1038/sj.bjp.0701186
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Abstract: 1 The pyridopyrimidine derivative IQM-95,333 ((4aS,5R)-2-benzyl-5-[N a -tert-butoxicarbonyl)L-tryptophyl]amino-1,3dioxoperhydropyrido [1,2-c] 3 Like devazepide, IQM-95,333 was a more potent antagonist of CCK-8S-than of CCK-4-induced contraction of the longitudinal muscle from guinea-pig ileum, suggesting selective antagonism at CCK A receptors. 4 IQM-95,333 and devazepide were also potent inhibitors of CCK-8S-stimulated amylase release from isolated pancreatic acini, a CCK A receptor-mediated e ect. The drug c… Show more

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Cited by 42 publications
(46 citation statements)
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“…The dissociation constants (K d ) for [ 3 H]-pCCK 8S binding to CCK 1 and CCK 2 receptors (0.5 and 1 nmol/l respectively) were similar to those previously reported [23,30]. IC 50 values obtained for the CCK 1 receptor antagonists devazepide and lorglumide and for the CCK 2 receptor antagonist PD 135,158 were also similar to those previously reported [18,20,36].…”
Section: Discussionsupporting
confidence: 72%
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“…The dissociation constants (K d ) for [ 3 H]-pCCK 8S binding to CCK 1 and CCK 2 receptors (0.5 and 1 nmol/l respectively) were similar to those previously reported [23,30]. IC 50 values obtained for the CCK 1 receptor antagonists devazepide and lorglumide and for the CCK 2 receptor antagonist PD 135,158 were also similar to those previously reported [18,20,36].…”
Section: Discussionsupporting
confidence: 72%
“…Amylase Release Dispersed rat pancreatic acini were prepared by using a modification of the technique of Ballaz et al [23]. The rats were killed and the pancreas was carefully cleaned.…”
Section: Experimental Designmentioning
confidence: 99%
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“…IQM-95,333 was a gift from Dr. M. T. García-López (Consejo Superior de Investigaciones Científicas Instituto de Química Médica, Madrid, Spain) (2). Rabbit polyclonal antibodies to c-jun, JunB, c-fos, ATF-3, Egr-1, lamin A/C, and JNK1 were from Santa Cruz Biotechnology (Santa Cruz, CA).…”
Section: Methodsmentioning
confidence: 99%