Pharmacological Effects of Aqueous Extract from Valeriana adscendens

Abstract

A purified aqueous extract of Valerianu adscendens Trel. (Valerianaceae) was investigated for its pharmacological profile. The extract did not exert significant changes on the nociceptive threshold in the hot plate and tail flick test and no effect was registered on the guinea-pig ileum. On the other hand, the extract significantly reduced both the locomotor activity and motor coordination of mice; it also prolonged sleep induced by pentobarbital, whereas no significant cataleptic response was observed. These effects may suggest neuroleptic-like properties.

Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice

“…Perez et al (1998) showed that a decrease in spontaneous motor activity resulted from a reduced excitability of the CNS and sedation (Ozturk et al, 1996). The decrease in spontaneous motor activity and potentiation of pentobarbital-induced sleep strongly suggest central depressant activity (Perez et al, 1998) of the fraction, thus suggesting that the fraction might be acting as a mild neurosedative drug (Capasso et al, 1996).…”

Evaluation of sedative and anticonvulsant activities of Unmadnashak Ghrita

“…(Ali et al, 1995). It seems probable that the UG did not act through peripheral neuromuscular blockage, but rather it evoked its action through centrally located mechanism centrally and thus acts as a CNS-depressant (Capasso et al, 1996). UG also inhibited MES induced seizures and PTZ induced seizures in mice.…”

Neuropharmacological activity of hydroalcoholic extract of leaves ofColocasia esculenta

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