Pharmacological Developments Obtained from Marine Natural Products and Current Pipeline Perspective

Galeano, Elkin; Rojas, John; Martínez, Alejandro Martínez

doi:10.1177/1934578x1100600233

Cited by 7 publications

(2 citation statements)

References 110 publications

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“…Anilide Fatty acid, stearic acid anilide (10), which was annotated from the mass ion of m/z 360.327 the corresponding molecular formula C24H41NO was also described [15].…”

Section: Metabolic Profilingmentioning

confidence: 99%

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Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies

Hassan

elhawary

Emam³

et al. 2022

Egypt. J. Chem.

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The most catastrophic problem that affects living standards is viral infections. This work aims to discover and evaluate new antiviral agents from marine sources. Antiviral activities of n-hexane, dichloromethane, ethyl acetate, and butanol fractions of octocoralNephtheasp. were examined in vitro against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses using MTT assay. n-hexane fraction was the most bioactive fraction with IC50 30.23 ± 0.007g/ml on both viruses. The metabolic profiling of the n-hexane fraction was investigated as the most potent fraction via the Ultra Performance Liquid Chromatography method joined to a quadrupole time-of-flight hybrid mass spectrometer (UPLC-Q/TOF-MS), which led to the identification of twelve secondary metabolites (diterpenoid, triterpene, steroids, and fatty acids). A molecular docking investigation was supported by using Molecular Operating Environment (MOE) software to prove the mechanism of action. The highest binding energy score was for lauric acid with -10.2157 kcal/mol toward the Thymidine Kinase (TK), and Chabrolohydroxybenzoquinone G toward 3C protease (3Cpro) enzyme with -16.5115 kcal/mol. Finally, the results were confirmed by the inhibitory effect of bioactive fraction in-vitro against TK and 3Cpro enzymes. Our results highlighted Nephtheasp. as a rich source of non-polar effective constituents that might be a promising candidate for controlling viral infections.

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“…Anilide Fatty acid, stearic acid anilide (10), which was annotated from the mass ion of m/z 360.327 the corresponding molecular formula C24H41NO was also described [15].…”

Section: Metabolic Profilingmentioning

confidence: 99%

“…Surveying for natural medicine, obtained from marine soft coral having antiviral activity represent an important step in finding an alternative viral disease treatment [10]. Secondary metabolites are prevalent in the family Nephtheidae.…”

Section: Introductionmentioning

confidence: 99%

Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies

Hassan

elhawary

Emam³

et al. 2022

Egypt. J. Chem.

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Synthetic Approaches Towards the Marine Alkyl Purines

Gordaliza

Pg²

2013

CMC

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Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids usually having a 9-methyladenine moiety.

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Synthetic Strategies to Terpene Quinones/Hydroquinones

Gordaliza

2012

Marine Drugs

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The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.

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Pharmacological Developments Obtained from Marine Natural Products and Current Pipeline Perspective

Cited by 7 publications

References 110 publications

Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies

Bioactive constituents of Marine Soft Coral Nephthea sp. against Herpes simplex type I (HSV-1) and Coxsackie B4 (CoxB4) viruses; In-Vitro and In Silico studies

Synthetic Approaches Towards the Marine Alkyl Purines

Synthetic Strategies to Terpene Quinones/Hydroquinones

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