Pharmacological aptitude and profiling of active constituent from Otostegia limbata-Comprehensive review

Sadaf, Huma Mehreen; Bibi, Yamin; Riaz, Iqra; Saboon,; Sultan, Muhammad Asim; Bibi, Fatima; Bibi, Muhammadi; Hussain, Mubashir; Sabir, Sidra

doi:10.1016/s2222-1808(16)61156-8

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…The GC-MS analysis of O. limbata identified a number of volatile compounds that were reported to possess antioxidant, anti-inflammatory, and neuroprotective potential ( Krishnamoorthy and Subramaniam, 2014 ; Salehi et al, 2019 ). Previous researchers suggested that the presence of limbatolide A, B, C, D limbatenolide-E, eupatorin and 3′-O-methyl eupatorin, and ballotenic and ballodiolic acids are terpenoids and flavones found in O. limbata ( Sadaf et al, 2016 ). Our study focuses on the antiepileptic potential of O. limbata mediated through the balancing excitatory (glutamate) and inhibitory gamma-aminobutyric acid (GABA) brain monoamines and inhibition of p-NFkB/TLR-4 pathway to ameliorate neuroinflammation (TNF-a, IL-1b, and COX-2).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α

et al. 2022

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Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures. Currently available antiepileptic drugs have severe side effects and do not offer complete cure. Herbal remedies have been used for centuries to treat many neurodegenerative disorders. Otostegia limbata L. belongs to the largest and medicinally important family Lamiaceae and is distributed in hilly areas of Pakistan. This study was designed to assess the antioxidant, anti-inflammatory, and anticonvulsant potential of O. limbata. The methanolic extract showed significant antioxidant activity assessed by (1,1-diphenyl 2-picrylhydrazyl) free-radical scavenging assay, nitric oxide scavenging, and iron chelation antioxidant assays. The methanolic extract was evaluated for its anticonvulsant effect, employing the pentylenetetrazole (PTZ)-induced mice model of epilepsy. Three different doses of O. limbata (100, 200, and 300 mg/kg) were administered orally 30 min before PTZ [50 mg/kg, intraperitoneal (i.p.)] injection, while diazepam was used as a positive control. The extract at 300 mg/kg significantly decreased the duration and increased the latency of the PTZ-induced seizures. The expression of inflammatory cytokines tumor necrosis factor α (p-TNF-α) and phosphorylated transcription factor nuclear factor kappa B (p-NF-κB), in the cortex and hippocampus of the brains of treated mice were analyzed through enzyme-linked immunosorbent assay and western blot analysis. The morphological changes and number of surviving neurons were recorded through hematoxylin and eosin staining. The seizure score and survival rate of the treated group showed considerable differences as compared to the PTZ group. TNF-α and p-NF-K b expression were downregulated as compared to the PTZ group. The anticonvulsant effect may be the outcome of the antioxidant potential and high levels of phenols and flavonoids detected in the methanolic plant extract through Fourier transform infrared spectrophotometer and gas chromatography–mass spectrometry analysis.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α

et al. 2022

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Polarity guided extraction, HPLC based phytochemical quantification, and multimode biological evaluation of Otostegia limbata (Benth.) Boiss

Fatima

Kainat

Akbar

2022

Arabian Journal of Chemistry

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Formulation and Evaluation of Antibacterial Cream from Mimosa Pudica and Tridax Procumbenz)

Sathe Pratiksha Dattatray,

Mane Priyanka Babaji,

Nichit Pranit Ganesh

2024

IJARSCT

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The study was carried out to identify through scientific methods the active ingredients and the pharmacological activities of the shoot and root extracts of Mimosa pudica Linn. The Mimosa pudica shoot methanolic extract (MSME),Mimosa pudica root methanolic extract (MRME) showed very good wound healing activity when compared to the standard drug Gentamicin. Tridax procumbens L. (Compositae) is a common weed that grows in the rice fields of India. Traditionally the juice from leaves of Tridax procumbens has been used for healing dermal wound. However, in experimental studies, equivocal pro and anti-healing action of T. Procumbens has been demonstrated. It has been studied previously that stage of wound healing involves acute inflammatory phase followed by the synthesis of collagen and other extra cellular macromolecules, which is later removed to form a scar

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Pharmacological aptitude and profiling of active constituent from Otostegia limbata-Comprehensive review

Cited by 3 publications

References 28 publications

Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α

Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α

Polarity guided extraction, HPLC based phytochemical quantification, and multimode biological evaluation of Otostegia limbata (Benth.) Boiss

Formulation and Evaluation of Antibacterial Cream from Mimosa Pudica and Tridax Procumbenz)

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