2017
DOI: 10.5812/aapm.42747
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: ContextVisceral pain is a leading symptom for patients with irritable bowel syndrome (IBS) that affects 10% - 20 % of the world population. Conventional pharmacological treatments to manage IBS-related visceral pain is unsatisfactory. Recently, medications have emerged to treat IBS patients by targeting the gastrointestinal (GI) tract and peripheral nerves to alleviate visceral pain while avoiding adverse effects on the central nervous system (CNS). Several investigational drugs for IBS also target the periphe… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
44
0
2

Year Published

2018
2018
2022
2022

Publication Types

Select...
6
1
1
1

Relationship

2
7

Authors

Journals

citations
Cited by 59 publications
(46 citation statements)
references
References 98 publications
0
44
0
2
Order By: Relevance
“…Although the origin of serotonin released in those experiments was not determined, in conditions of colonic hypersensitization, like irritable bowel syndrome (IBS), serotonin may be released from intestinal mast cells, contributing to abdominal pain . This underlies the analgesic effect of 5‐HT 3 antagonists in IBS, with increased intestinal transit time (also seen here) and constipation as their main adverse effects, and might also be involved in granisetron effects (alone or combined with cisplatin) on colonic sensitivity.…”
Section: Discussionmentioning
confidence: 84%
“…Although the origin of serotonin released in those experiments was not determined, in conditions of colonic hypersensitization, like irritable bowel syndrome (IBS), serotonin may be released from intestinal mast cells, contributing to abdominal pain . This underlies the analgesic effect of 5‐HT 3 antagonists in IBS, with increased intestinal transit time (also seen here) and constipation as their main adverse effects, and might also be involved in granisetron effects (alone or combined with cisplatin) on colonic sensitivity.…”
Section: Discussionmentioning
confidence: 84%
“…Since stress‐related disorders include anxiety and depression, and the development of irritable bowel syndrome have mutual influences, several researches have reported that psychological stress or negative affective symptoms could precipitate or exacerbate IBS through this axis . The effects of antidepressants, anxiolytics, and even antipsychotics in the treatment of IBS also hint at the correlations between IBS and psychiatric disorders. The recent development of probiotics also found that gut flora could play a role in the development and management of IBS …”
Section: Discussionmentioning
confidence: 99%
“…were harvested for simultaneous extracellular recordings from teased nerve filaments as detailed previously [24]. Mice were anesthetized by isoflurane inhalation, euthanized by exsanguination from perforating the right atrium, and perfused through the left ventricle with oxygenated Krebs solution (in mM: 117.9 NaCl, 4.7 KCl, 25 NaHCO 3 , 1.3 NaH 2 PO 4 , 1.2 MgSO 4 , 2.5 CaCl 2 , and 11.1 Dglucose).…”
Section: Extracellular Recordings From Mouse Sciatic Nervementioning
confidence: 99%
“…The distal end of the sciatic nerve (~5 mm) was gently pulled into a recording compartment filled with mineral oil and carefully split (i.e., teased) into fine neural filaments (~25 ÎŒm thick) for extracellular recordings of action potentials. Extracellular recordings from multiple teased nerve filaments were conducted by a custom-built 5-channel electrode array consisting of micro-wires deployed parallel to each other with ~150 ÎŒm clearance as described previously [24]. Action potentials were evoked at the un-teased end of the sciatic nerve using a platinum-iridium electrode (FHC Inc., ME).…”
Section: Extracellular Recordings From Mouse Sciatic Nervementioning
confidence: 99%