Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia

Jaehne, Emily J.; Salem, Abdallah; Irvine, Rodney J.

doi:10.1007/s00213-007-0825-9

Cited by 24 publications

(29 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Equipment The apparatus used was the same as we have used previously (Jaehne et al 2005(Jaehne et al , 2007 and based on previous studies (Florez-Duquet et al 2001;Gordon 1987). It consists of an insulated aluminum floor (120 cm) with an actual runway length of 72 cm divided into five zones with dimensions 14.5 by 30 cm.…”

Section: Methodsmentioning

confidence: 99%

“…injection at a dose of 40 μmol/kg, which equates to 9.19 mg/kg MDMA. This dose was chosen based on our previous work (Jaehne et al 2007). MDMA was obtained from the Australian Government Analytical Laboratories (Sydney, Australia).…”

Section: Methodsmentioning

confidence: 99%

“…Although behavior has been recognized as important in the overall control of core body temperature (Attia 1984;Sessler 1997), its role in stimulant-induced hyperthermia has only recently been studied (Jaehne et al 2005(Jaehne et al , 2007. The first of those studies placed rats in a thermal gradient after their body temperature had been increased or decreased by treatment with MDMA (10 mg/kg), and showed that rats chose appropriate ambient temperatures to bring their core temperature back to normal (Jaehne et al 2005).…”

mentioning

confidence: 99%

“…The first of those studies placed rats in a thermal gradient after their body temperature had been increased or decreased by treatment with MDMA (10 mg/kg), and showed that rats chose appropriate ambient temperatures to bring their core temperature back to normal (Jaehne et al 2005). The second was a dose-response study and showed that with increasing doses of MDMA (4-40 μmol/kg), the core temperature of rats increased and the preferred temperature on the thermal gradient decreased (Jaehne et al 2007). Thus, the ability to behaviorally thermoregulate may play a major role in reducing harms associated with stimulant-induced hyperthermia.…”

mentioning

confidence: 99%

See 3 more Smart Citations

The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes

2008

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes

2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…METH abuse triggers behavioral symptoms, including agitation, anxiety, paranoia, psychosis, and aggression (26,27,30); a variety of cardiovas-cular problems (31,32); reactive microgliosis (33); and hyperthermia and convulsions (34). METH users with HIV have also shown more neuronal injury and cognitive impairment due to HIV than individuals who do not abuse the drug (1,35).…”

mentioning

confidence: 99%

Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage

Sánchez

Varano

Rozieres

et al. 2016

Antimicrob Agents Chemother

View full text Add to dashboard Cite

b HIV-1 infection frequently causes HIV-associated neurocognitive disorders (HAND) despite combination antiretroviral therapy (cART).Evidence is accumulating that components of cART can themselves be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine, seems to aggravate HAND and compromise antiretroviral therapy. However, the combined effect of virus and recreational and therapeutic drugs on the brain is poorly understood. Therefore, we exposed mixed neuronal-glial cerebrocortical cells to antiretrovirals (ARVs) (zidovudine [AZT], nevirapine [NVP], saquinavir [SQV], and 118-D-24) of four different pharmacological categories and to methamphetamine and, in some experiments, the HIV-1 gp120 protein for 24 h and 7 days. Subsequently, we assessed neuronal injury by fluorescence microscopy, using specific markers for neuronal dendrites and presynaptic terminals. We also analyzed the disturbance of neuronal ATP levels and assessed the involvement of autophagy by using immunofluorescence and Western blotting. ARVs caused alterations of neurites and presynaptic terminals primarily during the 7-day incubation and depending on the specific compounds and their combinations with and without methamphetamine. Similarly, the loss of neuronal ATP was context specific for each of the drugs or combinations thereof, with and without methamphetamine or viral gp120. Loss of ATP was associated with activation of AMP-activated protein kinase (AMPK) and autophagy, which, however, failed to restore normal levels of neuronal ATP. In contrast, boosting autophagy with rapamycin prevented the long-term drop of ATP during exposure to cART in combination with methamphetamine or gp120. Our findings indicate that the overall positive effect of cART on HIV infection is accompanied by detectable neurotoxicity, which in turn may be aggravated by methamphetamine.

show abstract

The Drug Information and Monitoring System (DIMS) in the Netherlands: Implementation, results, and international comparison

Brunt

Niesink

2011

Drug Testing and Analysis

View full text Add to dashboard Cite

The Ministry of Health in the Netherlands has made illicit drug testing for drug users possible since the 1990s, in order to prevent serious health hazards associated with unexpected dangerous substances. This system of illicit drug testing is called the Drug Information and Monitoring System (DIMS). In nearly two decades, more than 100 000 drug samples have been handed in at DIMS testing facilities. This review describes the DIMS methodology and overviews results of the three main psychostimulant drug markets that have been monitored, i.e. ecstasy, amphetamine (speed), and cocaine. Additionally, monitoring results of hallucinogens are also described for the first time. For comparison, alternative international monitoring systems are described briefly alongside some of their results. Finally, drug monitoring is discussed from the perspectives of policy, prevention, and the drug users themselves.

show abstract

Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia

Abstract: These results suggest that behavioral aspects of thermoregulation are important in assessing the potential of individual drugs to cause harmful increases in core temperature.

Cited by 24 publications

References 51 publications

The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes

The effect of long-term repeated exposure to 3,4-methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes

Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage

The Drug Information and Monitoring System (DIMS) in the Netherlands: Implementation, results, and international comparison

Contact Info

Product

Resources

About