Pharmacological activity of Guarana (Paullinia cupana Mart.) in laboratory animals

Espinola, E.B.; Dias, R.F.; Mattei, Rita; Carlini, E. A.

doi:10.1016/s0378-8741(96)01506-1

Cited by 117 publications

(85 citation statements)

References 9 publications

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“…The ability of adaptogens to increase work capacity and physical performance has often been assessed using the swimming test in rodents, under different experimental conditions. Indeed, both adaptogens and antidepressants can increase the amount of time that an animal is able to keep swimming actively (Brekhman and Dardymov, 1968;Espinola et al, 1977;Banerjee and Izquierdo, 1982;Singh et al, 1988;Wagner et al, 1994;Dhuley, 2000;Abidov et al, 2003).…”

Section: Drugsmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

151

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Rhodiola rosea L., or 'golden root', is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time.

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Section: Drugsmentioning

confidence: 99%

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Perfumi

Mattioli

2006

Phytotherapy Research

151

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“…The results observed in the MWMT did not reflect a general increase in motor activity due to chronic administration of EBPC and EPA extracts, since the same doses which induced increase in cognition and anti-amnesia effect, produced no increase ambulatory behavior in the OFT. In young and elderly normal volunteers, acute or chronic administration of guaraná produced no effects on cognition (Galduroz and Carlini, 1994;1996) Mattei et al (1998 and Espinola et al (1997) reported increase in physical capacity, and antiamnesia effects in rats and mice treated with guaraná seeds extract. However, rats treated with caffeine in a dosage similar to the amount found in the guaraná extract did not show betterment of their physical and mental performances (Espinola et al, 1997), suggesting that these effects were due to components present in the extract different from caffeine.…”

Section: Discussionmentioning

confidence: 96%

“…In young and elderly normal volunteers, acute or chronic administration of guaraná produced no effects on cognition (Galduroz and Carlini, 1994;1996) Mattei et al (1998 and Espinola et al (1997) reported increase in physical capacity, and antiamnesia effects in rats and mice treated with guaraná seeds extract. However, rats treated with caffeine in a dosage similar to the amount found in the guaraná extract did not show betterment of their physical and mental performances (Espinola et al, 1997), suggesting that these effects were due to components present in the extract different from caffeine. Saponins and tannins are known as active substances responsible for enhancing cognitive behavior observed with red ginseng (Simeray et al, 1982;Yoshizawa et al, 1987;Ying et al, 1994).…”

Section: Discussionmentioning

confidence: 96%

“…The xanthic bases of guaraná, however, do not explain all of these therapeutic actions. Rats treated with extracts of guaraná, but not with caffeine at a dose similar to that found in guaraná extract, had shown antioxidant (Mattei et al, 1998) and anti-amnesia effects (Espinola et al, 1997) in a passive avoidance test. Thus, its effects could to be due to the other(s) substance(s) than xanthines contents in extract.…”

Section: Introductionmentioning

confidence: 86%

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Effect of crude extract and its semi purified constituents from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) lucke] on cognitive performance in Morris water maze in rats

Otobone

Sanches

Nagae

et al. 2005

Braz. arch. biol. technol.

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“…Estudos realizados mostraram que, após uma administração única (3,0 e 30 mg/kg) ou crônica (0,3 mg/ml) de pó da semente de guaraná, reverteu-se parcialmente o efeito da escopolamina indicando um efeito positivo na aquisição de memória 14 ; Amburana cearensis (cumaru), cujo extrato inibiu a enzima em 100%. Planta rica em cumarina 15 , em Angelica gigas, seu fracionamento bio-guiado, utilizando-se a atividade inibitória da AchE, levou ao isolamento e identificação de uma nova cumarina e ao isolamento de mais 11 cumarinas já descritas na literatura 16 .…”

Section: Conclusõesunclassified

Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer

Trevisan¹,

Macedo²,

Meent³

et al. 2003

Quím. Nova

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Recebido em 12/12/01; aceito em 5/11/02 SCREENING FOR ACETYLCHOLINESTERASE INHIBITORS FROM PLANTS TO TREAT ALZHEIMER'S DISEASE. Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognite impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activities. These symptons of AD have been successfully treated with acetylcholinesterase (AchE) inhibitors (eg. galanthamine). There still is great interest in finding better AchE inhibitors. We use Ellmann's microplate assay and silica gel thin-layer chromatography (TLC) to screen natural products from plants as new sources of AchE inhibitors.Keywords: Alzheimer disease; plants; cholinesterase inhibitors. INTRODUÇÃONa última década, a maneira de se pesquisarem novos compostos biologicamente ativos sofreu grandes mudanças, principalmente devido aos avanços tecnológicos. A indústria farmacêutica tem um papel importante no desenvolvimento de novos métodos, os quais podem propiciar, de forma mais rápida, o surgimento de novos medicamentos no mercado 1 . Um dos mais importantes fatores para o sucesso no descobrimento de um fármaco novo é a diversidade química dos compostos a serem selecionados, cujas fontes podem ser: compostos sintéticos, produtos naturais ou química combinatória. Entre estas possibilidades, os produtos naturais são considerados como uma das maiores fontes de diversidade química 2 . A natureza é uma fonte de inestimável riqueza de novos medicamentos. Nos EUA e Inglaterra, aproximadamente 25% dos compostos ativos, nas prescrições atuais, foram identificados em plantas superiores 3 . A avaliação biológica 1 foi uma das mais significantes mudanças na área de produtos naturais nos últimos anos. O entendimento dos mecanismos da doença, acompanhado do aumento de testes com receptores e enzimas disponíveis, permitiram o desenvolvimento de sistemas eficientes e rápidos de bioensaios. Dessa forma, um bom sistema permite selecionar milhares de amostras em poucos dias 1,4 . A modernização dos ensaios permitiu a utilização de enzimas, receptores, DNA, entre outros alvos, para avaliação rápida de grandes quantidades de amostras. Dentre os bioensaios rápidos e sensí-veis, a utilização da enzima acetilcolinesterase é uma alternativa para a detecção e seleção de amostras com ação anticolinesterase.Entre os indivíduos idosos, ressaltam-se as anormalidades decorrentes da disfunção do sistema nervoso, como deficiências relativas à memória, à capacidade intelectual, à coordenação motora, ao equilíbrio, à postura, etc.A demência, embora possa ocorrer nas idades jovens por enfermidades cerebrais variadas, está ligada ao fenômeno de envelhecimento cerebral, acometendo indivíduos com idade superior a 65 anos. Admite-se que 10 a 15% destes indivíduos apresentam alguma forma de demência e, deste grupo, 50 a 60% sofrem de uma doença degenerativa de causa não totalmente conhecida denominada doença de Alzheimer 5-8 . A doença de Alzheimer está associada ...

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Pharmacological activity of Guarana (Paullinia cupana Mart.) in laboratory animals

Cited by 117 publications

References 9 publications

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice

Effect of crude extract and its semi purified constituents from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) lucke] on cognitive performance in Morris water maze in rats

Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer

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