Pharmacological activity of Elaeocarpus sphaericus

Abstract

Elaeocarpus sphaericus fruits are used in Ayurveda for mental diseases, epilepsy, asthma, hypertension, arthritis and liver diseases. Sequential petroleum ether (PE), benzene (BE), chloroform (CE), acetone (AE) and ethanol (EE) extracts (50–200 or 200 mg/kg, ip, or 200 mg/kg, po) of dried Elaeocarpus sphaericus fruits, pretreatment time 30–45 min, showed significant antiinflammatory action against both acute and sub‐acute models, analgesic, barbiturate‐hypnosis potentiation and antiulcerogenic activities in rats. All the extracts, except PE and EE decreased swim stress immobility in mice indicating some degree of antidepressant activity. All the extracts protected guinea‐pigs against bronchospasm induced by histamine and acetylcholine aerosols. Chemically, the extracts showed the presence of glycosides, steroids, alkaloids and flavonoids. Copyright © 2000 John Wiley & Sons, Ltd.

An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals

“…rudrakine, (-)elaeocarpine and (-)iso-elaeocarpine, flavonoids and glycosides. [1] The present investigation shows that EGA seeds have an antihyperglycemic activity in STZ-induced diabetic rats. However, further studies should be undertaken to identify the active hypoglycemic compounds and investigate the mechanism of action of the hypoglycemic activity of E. ganitrus .…”

An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals

“…rudrakine, (-)elaeocarpine and (-)iso-elaeocarpine, flavonoids and glycosides. [1] The present investigation shows that EGA seeds have an antihyperglycemic activity in STZ-induced diabetic rats. However, further studies should be undertaken to identify the active hypoglycemic compounds and investigate the mechanism of action of the hypoglycemic activity of E. ganitrus .…”

Untitled

“…The pulp of stony fruit may be useful in epilepsy and other mental disorders 11 . Moreover, some other studies reported that it exhibit various pharmacological activities i.e analgesic 12,13 , antiasthamatic 14 , antiinflammatory 15 , antihypertensive 16 hypoglycemic 17 , smooth muscle relaxant and hydrocholeretic 18 , antiulcerogenic 19 , anticonvulsant 20 , antimicrobial 21 . Earlier the fruits of Rudraksha used to be employed as auspicious and for getting rid of bad spirit 22 .…”

Phosphoinositide 3‐Kinase Inhibitors from Gladiolus Segetum Ker‐Gawl Corms Supported by Network Pharmacology

“…Additionally, PI3 K pathway inhibitors are being explored for treating inflammatory and autoimmune diseases, given their role in immune cell function. Understanding and targeting the PI3 K pathway holds promise for improving outcomes in cancer therapy and other diseases characterized by aberrant PI3 K signaling [37–39] …”

An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals

“…rudrakine, (-)elaeocarpine and (-)iso-elaeocarpine, flavonoids and glycosides. [1] The present investigation shows that EGA seeds have an antihyperglycemic activity in STZ-induced diabetic rats. However, further studies should be undertaken to identify the active hypoglycemic compounds and investigate the mechanism of action of the hypoglycemic activity of E. ganitrus .…”

Untitled

“…The pulp of stony fruit may be useful in epilepsy and other mental disorders 11 . Moreover, some other studies reported that it exhibit various pharmacological activities i.e analgesic 12,13 , antiasthamatic 14 , antiinflammatory 15 , antihypertensive 16 hypoglycemic 17 , smooth muscle relaxant and hydrocholeretic 18 , antiulcerogenic 19 , anticonvulsant 20 , antimicrobial 21 . Earlier the fruits of Rudraksha used to be employed as auspicious and for getting rid of bad spirit 22 .…”

Phosphoinositide 3‐Kinase Inhibitors from Gladiolus Segetum Ker‐Gawl Corms Supported by Network Pharmacology

“…Additionally, PI3 K pathway inhibitors are being explored for treating inflammatory and autoimmune diseases, given their role in immune cell function. Understanding and targeting the PI3 K pathway holds promise for improving outcomes in cancer therapy and other diseases characterized by aberrant PI3 K signaling [37–39] …”

An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals

“…rudrakine, (-)elaeocarpine and (-)iso-elaeocarpine, flavonoids and glycosides. [1] The present investigation shows that EGA seeds have an antihyperglycemic activity in STZ-induced diabetic rats. However, further studies should be undertaken to identify the active hypoglycemic compounds and investigate the mechanism of action of the hypoglycemic activity of E. ganitrus .…”

Untitled

“…The pulp of stony fruit may be useful in epilepsy and other mental disorders 11 . Moreover, some other studies reported that it exhibit various pharmacological activities i.e analgesic 12,13 , antiasthamatic 14 , antiinflammatory 15 , antihypertensive 16 hypoglycemic 17 , smooth muscle relaxant and hydrocholeretic 18 , antiulcerogenic 19 , anticonvulsant 20 , antimicrobial 21 . Earlier the fruits of Rudraksha used to be employed as auspicious and for getting rid of bad spirit 22 .…”

Phosphoinositide 3‐Kinase Inhibitors from Gladiolus Segetum Ker‐Gawl Corms Supported by Network Pharmacology

“…Additionally, PI3 K pathway inhibitors are being explored for treating inflammatory and autoimmune diseases, given their role in immune cell function. Understanding and targeting the PI3 K pathway holds promise for improving outcomes in cancer therapy and other diseases characterized by aberrant PI3 K signaling [37–39] …”