Pharmacokinetics of Myo-Inositol in a Wistar Rat Animal Model

Abstract

Myo-inositol is the most popular inositol in living organisms, where it is present as a sugar alcohol, in a free form, and can also be described as a lipid. The aim of this study was to check the concentration change of a myo-inositol solution from the time of oral administration and over a 48 h period in Wistar-type rats. All rats received 2 g/kg of inositol as a solution in distilled water by oral gavage. Estimated parameters were based on the serum concentration of myo-inositol observed in nine individual rats with regard to time. Observations were described as a one-compartment pharmacokinetic model with first-order absorption and zero-order endogenous input of checked inositol. The highest myo-inositol concentration was observed in the first hour after oral administration in the serum of all tested rats. Then, the concentration began decreasing immediately after the maximal peak. The inositol concentration continued to decrease, but after 24 h its level was still higher than before the administration. The plasma profile of the myo-inositol concentration showed a rapid decline over time, possibly due to the metabolism of this compound.

In silico and in vitro assessment of an optimized QbD-guided myoinositol and metformin-loaded mucus-penetrating particle-based gel for the amelioration of PCOS

“…1,2 Although insulin resistance (IR) does not directly inuence the diagnostic criteria of PCOS, it plays a key role in its pathogenesis (70-80% prevalence of IR has been reported). 3 The normal physiological mechanism of a healthy woman's ovary is comprised of a 99% intracellular pool of myoinositol (MI), while the remaining 1% is comprised of d-chiro-inositol (DCI). MI is a key factor in regulating the glucose uptake in the ovaries and FSH signaling, which is essential for the meiosis in follicles.…”