Pharmacokinetics of Da-125, a New Anthracycline, After Intravenous Administration to Uranyl Nitrate-Induced Acute Renal Failure Rats or Protein--Calorie Malnutrition Rats

Pharmacokinetics of a New Carbapenem, DA-1131, after Intravenous Administration to Rats with Uranyl Nitrate-Induced Acute Renal Failure

“…The impaired kidney function in U-ARF rats resulted in a significant decrease in the amounts of unchanged DA-1131 excreted in urine over 8 h (X U 0-8 ) compared with the amounts excreted unchanged from control rats (1.54 versus 43.8%) (Table 2). Similar results were also reported for DA-125 (17), adriamycin (18), methotrexate (20), and azosemide (21). Significant decreases in the values of CL, CL R , and/or CL NR after intravenous administration of vancomycin (7), amiodarone (8), diltiazem (19), azosemide (21), methotrexate (20), and DA-125 (17) to U-ARF rats have also been reported.…”

“…Similar results were also reported for DA-125 (17), adriamycin (18), methotrexate (20), and azosemide (21). Significant decreases in the values of CL, CL R , and/or CL NR after intravenous administration of vancomycin (7), amiodarone (8), diltiazem (19), azosemide (21), methotrexate (20), and DA-125 (17) to U-ARF rats have also been reported. The contribution of biliary excretion of unchanged DA-1131 to the CL NR of DA-1131 after intravenous administration of the drug to rats seemed to be minor, because less than 1.76% of the intravenous dose of DA-1131 was excreted as unchanged drug in bile over 8 h after the intravenous administration of DA-1131 at 200 mg/kg to four to six rats (15).…”

“…Creatinine clearance (CL CR ) was calculated by dividing the total amounts of creatinine excreted in urine over 8 h by the AUC from 0 to 8 h (AUC 0-8 ) for creatinine (the concentration of creatinine in plasma was measured 8 h after administration of the intravenous dose), assuming that the kidney function was stable during the 8-h experimental period. The kidney function seemed to be stable since the CL CR for the control rats (4.29 ml/min/kg; see Table 1) was very similar to the values reported in the literature (3 to 5 ml/min/kg) and the impaired kidney function in U-ARF rats continued from the third day to the fifth day after a single injection of uranyl nitrate into the rats (12,17).…”

Effects of Cyclosporin on the Pharmacokinetics of Propranolol after Intravenous and Oral Administration to Control Rats and to Rats with Uranyl Nitrate-induced Acute Renal Failure

“…Note that body weight gain was signi®cantly reduced by pretreatment with uranyl nitrate (from 273AE 13Á1 to 243AE 21Á7 g) whereas it increased signi®cantly in control rats (from 268AE 18Á4 to 295AE 15Á9 g). Impaired kidney function in rats with uranyl nitrate-induced acute renal failure has been reported by other workers (Terao & Shen 1984;Kim 1991;Kim et al 1996Kim et al , 1998.…”

Effects of acute renal failure on the pharmacokinetics of oltipraz in rats

“…The decrease in oral absorption in rats with U‐ARF could be due to the fact that higher levels of waste products such as urea nitrogen in renal failure may alter gastric pH and induce edema of the gastrointestinal tract through local irritant properties 39. Significantly higher plasma levels of urea nitrogen in rats with U‐ARF have also been reported 8,10,26–29…”