Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles

Hitzman, Cory J.; Wattenberg, Lee W.; Wiedmann, Timothy S.

doi:10.1002/jps.20607

Cited by 59 publications

(47 citation statements)

References 27 publications

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“…Furthermore, an evaluation has to be made of whether inhaled chemotherapy is appropriate for early-stage lung cancer, or as neoadjuvant or adjuvant treatment. 57,60,61,230,231 Because lesions are of smaller size, drug deposition is not prevented by the large mass median diameter of the tumor. 131 Current drug delivery systems have demonstrated an ability to achieve sustained release locoregionally, but further improvement is welcomed.…”

Section: Resultsmentioning

confidence: 99%

“…32 This observation was confirmed in another study using 5-FU. 60 Moreover, additional formulations of 5-FU with lipid-coated nanoparticles or difluoromethylornithine, an important enzyme in cell proliferation, were devised to achieve sustained drug release and enhance anticancer properties. 60,230,231 In these studies, previously presented for their inhalable system carriers with 5-FU, a step was made forward in using inhaled chemotherapy as an adjuvant treatment.…”

Section: Inhalation Studiesmentioning

confidence: 99%

“…60 Moreover, additional formulations of 5-FU with lipid-coated nanoparticles or difluoromethylornithine, an important enzyme in cell proliferation, were devised to achieve sustained drug release and enhance anticancer properties. 60,230,231 In these studies, previously presented for their inhalable system carriers with 5-FU, a step was made forward in using inhaled chemotherapy as an adjuvant treatment. Studies using taxanes either with liposome carriers, nanoparticles, polymeric micelles, or lipid nanocapsules provided evidence of an increased therapeutic index by prolonging regional action in the lung.…”

Section: Inhalation Studiesmentioning

confidence: 99%

“…34,39,40,[47][48][49][50][51]53,[55][56][57][58][59][60] Transporters could be used in addition as a prognostic factor. 199 Moreover, regarding carriers, liposomes would appear to require dosing three or four times a day and would be expected to be well tolerated within the lung following repeated dosing.…”

mentioning

confidence: 99%

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Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Zarogoulidis

Chatzaki²,

Porpodis³

et al. 2012

IJN

166

160

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Regional chemotherapy was first used for lung cancer 30 years ago. Since then, new methods of drug delivery and pharmaceuticals have been investigated in vitro, and in animals and humans. An extensive review of drug delivery systems, pharmaceuticals, patient monitoring, methods of enhancing inhaled drug deposition, safety and efficacy, and also additional applications of inhaled chemotherapy and its advantages and disadvantages are presented. Regional chemotherapy to the lung parenchyma for lung cancer is feasible and efficient. Safety depends on the chemotherapy agent delivered to the lungs and is dose-dependent and time-dependent. Further evaluation is needed to provide data regarding early lung cancer stages, and whether regional chemotherapy can be used as neoadjuvant or adjuvant treatment. Finally, inhaled chemotherapy could one day be administered at home with fewer systemic adverse effects.

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Section: Resultsmentioning

confidence: 99%

Section: Inhalation Studiesmentioning

confidence: 99%

Section: Inhalation Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Zarogoulidis

Chatzaki²,

Porpodis³

et al. 2012

IJN

166

160

View full text Add to dashboard Cite

show abstract

“…The concentration of the encapsulated camptothecin in the lung was 100 times higher following airways administration than after intramuscular injection . Similarly, the concentration of aeorosolised 5-Fluorouracile (5-FU) in the lung tissue was 1000 times higher than in the serum of hamsters (Hitzman et al, 2006). High concentrations of 5-FU were detected in the trachea and bronchi of dogs after airways delivery, whereas a lower concentration was measured in the peripheral lung (Tatsumura et al, 1993).…”

Section: 1 Lung Depositionmentioning

confidence: 99%

The Airways: A Promising Route for the Pulmonary Delivery of Anticancer Agents

Guilleminault¹,

Hervé-Grépinet²,

Lemarié³

et al. 2011

Advances in Cancer Therapy

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Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment

Tian

Chen

2014

Chin. J. Chem.

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Pulmonary drugs and genes delivery systems have become an attractive approach in the treatment of lung diseases with the advantages of minimal drug loss, precise quantization, high local drugs concentration and low side effects. However, special attention should be paid to the biological barriers of the lung. The delivery systems need to be designed carefully in order to overcome these biological barriers and maximize the drugs and genes deposition to the lungs. Pulmonary drugs and genes delivery systems can offer some encouraging results for delivering drugs and genes to the lungs. Specifically, some lipid‐based and polymer‐based delivery systems could control and sustain the release of drugs and genes with minimal or negligible toxicity. This review focuses on the latest development of pulmonary delivery of drugs and genes for the treatment of various lung diseases. The barriers to the lung, the delivery devices, the route of the administration and the delivery systems for drugs and genes pulmonary delivery are described. Based on the rapid development of clinical requirement, novel approaches using delivery systems for pulmonary delivery drugs and genes need to be constructed, which is believed to play an important role in the therapy of lung diseases in the future.

show abstract

Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles

Cited by 59 publications

References 27 publications

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

Inhaled chemotherapy in lung cancer: future concept of nanomedicine

The Airways: A Promising Route for the Pulmonary Delivery of Anticancer Agents

Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment

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