Pharmacokinetics and tissue distribution of the antileukaemic organoarsenicals arsthinol and melarsoprol in mice

Theoretical calculations of the relative pKa values of some selected aromatic arsonic acids in water using density functional theory

“…Organo arsenic compounds despite their toxicity gets revived attention due to pharmaceutical use. [1][2][3][4] For example Carbarsone is an organoarsenic compound with antiprotozoal activity which is used against of the amebiasis. [5][6][7] They also are under consideration from the biological activity point of view yet.…”

Anticancer Activity of Molecular Compounds of Arsenic, Antimony and Bismuth

“…A precise mechanism of action for Trisenox remains unknown and studies investigating the interaction of arsenic with biomolecules continue [25][26][27][28]. Patients suffering from acute promyelocytic leukaemia (AML) are characterized by an accumulation of immature granulocytes (i.e., promylelocytes: a category of white blood cells with granules in their cytoplasm) in their bone marrow.…”

Arsenic in Human History and Modern Societies

“…Today, arsenic medicines have been largely replaced by less toxic compounds (Gorby, 1994), 6. However, arsenic compounds are still recognized as having beneficial uses in treating certain diseases, including some types of leukemia ( (Francesconi and Kuehnelt, 2004), 374; (Oremland and Stolz, 2003), 939;(Ben Zirar et al, 2007); Chapter 4). For example, As 2 O 3 is utilized to treat patients with acute promyelocytic leukemia (Zhu et al, 1999;Shen et al, 1997).…”