Pharmacokinetics and anthelmintic efficacy of febantel in the racing pigeon (Columba livia)

Abstract

This paper reports on the pharmacokinetics and the efficacy of febantel against Capillaria obsignata and Ascaridia columbae in the racing pigeon. Febantel was rapidly cleared from the circulation and highly metabolized. The efficacy of febantel against Capillaria and Ascaridia was studied on lightly and heavily infected pigeons. The efficacy against Ascaridia was 100% for the faecal egg count reduction (FECR) as well as for the worm reduction in all treated pigeons. After two treatments with febantel against Capillaria in heavily infected pigeons the FECR amounted to 96.7% and worm reduction was 95%. In order to effectively remove both parasites from the host, repeated treatments with febantel at a short interval could be the treatment of choice.

Efficacy of Orally Administered Febantel against Monogenean Heterobothrium okamotoi infection of Cultured Tiger Puffer Takifugu rubripes

“…These results are similar to those that have been observed in other animals (Baert et al, 1993;Debackere et al, 1993;Ben-Zvi et al, 1996).…”

“…In the present research, we examined the pharmacokinetics of febantel after oral administration to healthy tiger puffer, in order to determine if the drug is also metabolized to fenbendazole in tiger puffer as in other animals (Baert et al, 1993;Debackere et al, 1993;BenZvi et al, 1996), and also if febantel, more specifically fenbendazole, is absorbed into blood of the host. We also report the potentially significant anti-H. okamotoi activity of febantel in both tiger puffer experimentally infected and those naturally infected with this parasite.…”