Pharmacokinetic Profile and Efficacy of a Fentanyl Transdermal Delivery System for Acute Postoperative Pain after Intra‐abdominal Gynecologic Surgery for Cancer

Abstract

The transdermal therapeutic system for administration of fentanyl, combined with epidural administration of a nonopioid analgesic such as bupivacaine is effective in controlling postoperative pain after gynecologic surgery. Additionally, the safety/tolerability of this regimen was similar to placebo plus bupivacaine.

Efficacy and Safety of Transdermal Fentanyl in the Control of Postoperative Pain After Photorefractive Keratectomy

“…10 However, in most of these cases the specific causes are difficult to evaluate because of the concomitant use of other opioids such as morphine, [29][30][31][32][33][34][35] which may enhance respiratory depression. 10 Also, in these cases surgeries were performed under general anesthesia and TDF was delivered at much higher rates (ranging 50-100 mg/h) than in the present study (12 mg/h). A recent study using the same TDF patch as used in our study (Durogesic TTS) reported analgesic efficacy and safety of this transdermal system.…”

“…Previous studies have administered premedication with TDF 1-2 h before surgery; this resulted in mostly favorable outcomes. 10,[29][30][31][32][33] In our study, TDF was administered 2 h preoperatively. However, our results suggest the need for further evaluation of earlier premedication with TDF and/or additional adjuvant medication to efficiently cope with early postoperative pain after PRK.…”

“…TDF delivery offers benefits of simplicity, efficacy, and widespread patient acceptance. 9,10 Because of its potency and simplicity, we thought TDF could be helpful in decreasing severe pain after PRK, via outpatient treatment, with rigid monitoring of adverse effects.…”

Analgesia multimodal para el postoperatorio en la enfermedad renal crónica: fentanilo transcutáneo, fentanilo oral transmucosa y metamizol

“…El fentanilo tiene el mismo metabolismo hepático que el resto de los opiá-ceos pero su metabolito es inactivo. La presentación en sistemas de liberación transcutánea se ha empleado en el manejo del dolor postoperatorio, a dosis de 50 microgramos/hora, aunque debido a su farmacocinética no es una elección habitual (7). El tiempo que transcurre hasta conseguir un efecto máximo es de 12 a 48 horas (8).…”

418 the Clinical and Laboratorial Evaluation of Transdermal Ketamine, Fentanyl, Clonidine or Their Combination in Chronic Low Back Pain

“…However, although clinical evaluation revealed to some extent benefit of all T drugs tested, the laboratorial data revealed that administration of T fentanyl alone (FenG) resulted in plasma noradrenaline decrease at 6-h compared to itself at the 0-h. Although the minimum effective concentration of T fentanyl in serum (0.63 ng/mL) was achieved at 11.3 ± 4.9 hours after application 11 , fentanyl as a cream preparation took less than six hours, and was indirectly supported by the decreased plasma noradrenaline serum levels. In addition, the association of T fentanyl with clonidine resulted in plasma noradrenaline decrease even at 3-and 6-h, compared to either drug alone or to the other groups, corroborating to the clinical data.…”