Pharmaceutical suspensions: micro electrophoretic properties

Abstract

The microelectrophoretic properties of the drugs griseofulvin, betamethasone, nalidixic acid and thiabendazole in aqueous dispersion have been examined and the zeta potentials calculated from the measured mobilities. Variation in magnitude of particle charge with pH of dispersion is reported and related to the chemical structure and surface characteristics. The effect of adding anionic (sodium dodecyl sulphate) cationic (dodecyl trimethyl bromide) and non‐ionic (polyoxyethylene glycol monoethers of hexadecanol) surface‐active agents, and mixtures of these ionic and non‐ionic species, on the electrophoretic properties of the drug dispersions has been measured. The results reported agree with those found previously for a model polystyrene latex suspension system under the same conditions.

Otimização de suspensões de benzoilmetronidazol

“…Contudo, a simp determinação do potencial zeta da substância a ser dispersa e a adição do tensoativo n conduzem a formação de um sistema floculado. Para que esta condição ocorra é necessá a redução do potencial zeta do sistema (25,82,84,112,134).…”

Impact of Vehicle Physicochemical Properties on Modeling-Based Predictions of Cyclosporine Ophthalmic Emulsion Bioavailability and Tear Film Breakup Time

“…Emulsion stability is significantly influenced by zeta potential. 6,19 For this study, it was considered both desirable and feasible to develop models which predict bioavailability and TBUT based on vehicle physicochemical properties. Specifically, the models consider the effects of differences in viscosity, surface tension, and osmolality of Q1 and Q2 cyclosporine ophthalmic emulsions on predictions of human conjunctival and corneal bioavailability and TBUT.…”

Development of surfactant coacervation in aqueous solution

“…Coacervation has attracted particular interest because of its widespread applications in water treatment, 1,2 cosmetic formulation, 3,4 protein purication, 5,6 tissue elasticity, 7 and pharmaceutical microencapsulation. [8][9][10] Coacervation is dened as a process in which a colloidal dispersion separates into two immiscible liquid phases in the same solvent medium. The dense phase which is rich in colloidal components is called the coacervate, and it is in equilibrium with a relatively dilute liquid phase.…”