Abstract:Covalent attachment
of a ferric hemoglobin (metHb) core
to three
human serum albumin molecules to form metHb-albumin clusters has previously
been used to develop an antidote for hydrogen sulfide poisoning. Lyophilization
is one of the most effective approaches to preserve protein pharmaceuticals
with minimum contamination and decomposition. However, there is concern
that lyophilized proteins may undergo pharmaceutical alteration on
reconstitution. This study investigated the pharmaceutical integrity
of metHb-a… Show more
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