volume 275, issue 1-2, P1-12 2004
DOI: 10.1016/j.ijpharm.2004.01.034
View full text
|
|
Share

Abstract: Early development candidates are often selected for pre-clinical and clinical development based primarily on pharmacological and toxicological data. In order to choose the best compounds from a biopharmaceutical point of view, physicochemical parameters such as solubility, dissolution rate, hygroscopicity, lipophilicity, pKa, stability, polymorphism and particle characteristics need to be evaluated as early as possible and above all with the highest accuracy. However, the low amounts of drug substance availabl…

expand abstract