1977
DOI: 10.1001/archderm.113.2.147
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Phagocyte function and cell-mediated immunity in systemic lupus erythematosus

Abstract: Lymphocyte, granulocyte, and macrophage function were studied simultaneously in 26 untreated patients with systemic lupus erythematosus (SLE) and 26 matched controls. The overall cellular response, as assessed in vivo by skin tests and sensitization to dinitrochlorobenzene, was diminished in the SLE group. Although T cells were reduced in number in patients with SLE, their function appeared unimpaired, as shown by normal lymphocyte transformation to phytohemagglutinin and bacterial and fungal antigens. The dep… Show more

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Cited by 13 publications
(9 citation statements)
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“…In concordance with previous studies demonstrating defective phagocytosis (61)(62)(63)(64), our findings show a decreased and delayed engulfment capacity of in vitro-differentiated SLE M$ for apoptotic cells, although these processes use different sets of reccptors (43,47,49.50,70). In addition, there are separate pathways to recognizing different types of apoptotic cells, e.g., apoptotic granulocytes and lymphocytes, respectively (71).…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…In concordance with previous studies demonstrating defective phagocytosis (61)(62)(63)(64), our findings show a decreased and delayed engulfment capacity of in vitro-differentiated SLE M$ for apoptotic cells, although these processes use different sets of reccptors (43,47,49.50,70). In addition, there are separate pathways to recognizing different types of apoptotic cells, e.g., apoptotic granulocytes and lymphocytes, respectively (71).…”
Section: Discussionsupporting
confidence: 92%
“…A reduced phagocytic activity of SLE patients' polymorphonuclear leukocytes (PMN), monocytes, and M+ is well established (61)(62)(63)(64). SLE-derived PMN displayed an impaired capacity to ingest zymosan particles (65), and M+ were reported to have a reduced uptake of yeast (63), opsonized Escherichiu coli (21), and other targets (64).…”
mentioning
confidence: 99%
“…75 Phagocytosis by PMNs was also found to be deeply depressed in SLE patients. 76 Furthermore, phagocytosis by PMNs under inflammatory conditions is impaired in the autoimmune mouse strain MRL/lpr. 77 We are currently investigating the phagocytic function of PMNs from healthy donors, from RA patients, and from SLE patients under noninflammatory conditions.…”
Section: Clearance Deficiency In Slementioning
confidence: 99%
“…detected TUNEL positive glomerular cells in lupus patients 46 . Accumulation of apoptotic chromatin in the glomeruli is assumed to be linked to decreased removal of apoptotic cells in SLE 43,45,48–50 . Normally, clearance of apoptotic cells is not associated with macrophage‐derived pro‐inflammatory signals.…”
Section: Intraglomerular Extra‐cellular Chromatin—an Apoptotic Originmentioning
confidence: 99%