pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia

Keshavarz, Hasan; Khavandi, Alireza; Alamolhoda, S.; Naimi-Jamal, Mohammad Reza

doi:10.1039/d0ra06916g

Cited by 30 publications

(9 citation statements)

References 46 publications

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“…Moreover, their size and shape can be easily controlled by using different synthesis methods [ 55 ]. It is possible to synthesize multifunctional platforms using Fe 3 O 4 nanoparticles, in which other compounds cover magnetite nanoparticles, such as SiO 2 , or even by the biodegradable polymers [ 56 , 57 , 58 ].…”

Section: Nanoparticlesmentioning

confidence: 99%

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

et al. 2022

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Until now, strategies used to treat cancer are imperfect, and this generates the need to search for better and safer solutions. The biggest issue is the lack of selective interaction with neoplastic cells, which is associated with occurrence of side effects and significantly reduces the effectiveness of therapies. The use of nanoparticles in cancer can counteract these problems. One of the most promising nanoparticles is magnetite. Implementation of this nanoparticle can improve various treatment methods such as hyperthermia, targeted drug delivery, cancer genotherapy, and protein therapy. In the first case, its feature makes magnetite useful in magnetic hyperthermia. Interaction of magnetite with the altered magnetic field generates heat. This process results in raised temperature only in a desired part of a patient body. In other therapies, magnetite-based nanoparticles could serve as a carrier for various types of therapeutic load. The magnetic field would direct the drug-related magnetite nanoparticles to the pathological site. Therefore, this material can be used in protein and gene therapy or drug delivery. Since the magnetite nanoparticle can be used in various types of cancer treatment, they are extensively studied. Herein, we summarize the latest finding on the applicability of the magnetite nanoparticles, also addressing the most critical problems faced by smart nanomedicine in oncological therapies.

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Section: Nanoparticlesmentioning

confidence: 99%

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

et al. 2022

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“…The Fourier transform infrared (FTIR) spectra of UCNPs along with UCNPs@mSiO 2 are shown in Figure S3, and the peaks are assigned as per the reported ones. 19,20 2.3.1. Upconversion Nanoparticles.…”

Section: Surface Functionalization Studymentioning

confidence: 99%

Mesoporous NaGdF₄/Ho–Yb@m-SiO₂ Upconversion Nanophosphors as a Potent Theranostic Probe

Joshi

Patra

Srivastava

et al. 2022

ACS Appl. Nano Mater.

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Nearly monodispersed NaGdF4/Ho–Yb upconversion nanoparticles (UCNPs) are synthesized by thermolysis of respective rare earth oleates. UCNPs are made biocompatible by mesoporous silica (m-SiO2) coating. These particles exhibit red and green bands in the visible range upon excitation at 980 nm laser. Interestingly, because of the presence of Ho3+ ions, these UCNPs can be excited via UV–vis light in addition to the 980 nm near infrared light. A systematic study is carried out to demonstrate the use of these UCNPs as drug (DOX) carriers. Toxicity studies and bio-imaging using DOX-loaded UCNPs have been demonstrated. UCNPs are also radiolabeled with 177Lu using m-SiO2 coating to demonstrate its potential application as a carrier of the therapeutic radionuclide in vivo for radionuclide therapy. Lu-177 adsorption studies are carried out extensively in order to understand the nature of adsorption, and it is found to be a combination of Langmuir and Freundlich isotherm models. Kinetics of adsorption of Lu3+ ions on the m-SiO2 coating of UCNPs is studied. Overall, the synthesis and physicochemical characterization of NaGdF4/Ho–Yb@m-SiO2 upconversion nanocrystals and their potential utilities in multimodal biomedical applications are amply demonstrated.

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“…Mesoporous silica nanoparticles (MSNs) have been broadly used as biomaterials owing to their advantageous characteristics like good biocompatibility, large surface area, well-defined mesoporous structure with tunable pore size, high drug encapsulation efficiency, and reactive surface [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. However, a major drawback of the MSNs is the inability to control the release of the encapsulated payload.…”

Section: Introductionmentioning

confidence: 99%

pH/Thermo-Responsive Grafted Alginate-Based SiO2 Hybrid Nanocarrier/Hydrogel Drug Delivery Systems

et al. 2021

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We report the preparation of mesoporous silica nanoparticles covered by layer by layer (LbL) oppositely charged weak polyelectrolytes, comprising poly(allylamine hydrochloride) (PAH) and a sodium alginate, highly grafted by N-isopropylacrylamide/N-tert-butylacrylamide random copolymers, NaALG-g-P(NIPAM90-co-NtBAM10) (NaALG-g). Thanks to the pH dependence of the degree of ionization of the polyelectrolytes and the LCST-type thermosensitivity of the grafting chains of the NaALG-g, the as-prepared hybrid nanoparticles (hNP) exhibit pH/thermo-responsive drug delivery capabilities. The release kinetics of rhodamine B (RB, model drug) can be controlled by the number of PAH/NaALG-g bilayers and more importantly by the environmental conditions, namely, pH and temperature. As observed, the increase of pH and/or temperature accelerates the RB release under sink conditions. The same NaALG-g was used as gelator to fabricate a hNP@NaALG-g hydrogel composite. This formulation forms a viscous solution at room temperature, and it is transformed to a self-assembling hydrogel (sol-gel transition) upon heating at physiological temperature provided that its Tgel was regulated at 30.7 °C, by the NtBAM hydrophobic monomer incorporation in the side chains. It exhibits excellent injectability thanks to its combined thermo- and shear-responsiveness. The hNP@NaALG-g hydrogel composite, encapsulating hNP covered with one bilayer, exhibited pH-responsive sustainable drug delivery. The presented highly tunable drug delivery system (DDS) (hNP and/or composite hydrogel) might be useful for biomedical potential applications.

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pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia

Abstract: Magnetite mesoporous silica nanoparticles coated with chitosan for simulanious hypertherima and chemotherapy.

Cited by 30 publications

References 46 publications

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Mesoporous NaGdF₄/Ho–Yb@m-SiO₂ Upconversion Nanophosphors as a Potent Theranostic Probe

pH/Thermo-Responsive Grafted Alginate-Based SiO2 Hybrid Nanocarrier/Hydrogel Drug Delivery Systems

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pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia

Abstract: Magnetite mesoporous silica nanoparticles coated with chitosan for simulanious hypertherima and chemotherapy.

Cited by 30 publications

References 46 publications

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Mesoporous NaGdF4/Ho–Yb@m-SiO2 Upconversion Nanophosphors as a Potent Theranostic Probe

pH/Thermo-Responsive Grafted Alginate-Based SiO2 Hybrid Nanocarrier/Hydrogel Drug Delivery Systems

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Mesoporous NaGdF₄/Ho–Yb@m-SiO₂ Upconversion Nanophosphors as a Potent Theranostic Probe