pH-Responsive supramolecular vesicles assembled by water-soluble pillar[5]arene and a BODIPY photosensitizer for chemo-photodynamic dual therapy

Meng, Lu-Bo; Zhang, Wenyi; Li, Dongqi; Li, Yan; Hu, Xiao‐Yu; Wang, Leyong; Li, Guigen

doi:10.1039/c5cc05785j

Cited by 127 publications

(72 citation statements)

References 48 publications

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“…Therefore, in the following work, a BODIPY-functionalized quaternary ammonium derivative G9 was synthesized, which acted as a photosensitizer and also as a guest to form a supramolecular amphiphile with WP5 based on host-guest interactions (Figure 7). [34] The resulting amphiphile formed from WP5 and G9 could further self-assemble into supramolecular vesicles, which could successfully encapsulate the chemotherapy drug DOX with good loading efficiency, and the formed DOX-loaded vesicles showed effective and rapid release of DOX in an acidic environment, making such systems promising candidates for controlled drug release. Moreover, the obtained supramolecular vesicles had good biocompatibility and the DOX-loaded vesicles could localize well in lysosomes and showed a remarkable combination of chemo-and photodynamic activities against A549 cancer cells upon irradiation with red light, suggesting that this is a potential DDS for chemo-photodynamic dual therapy.…”

Section: Pillararene-based Stimuli-responsive Sddss For Chemo-photodymentioning

confidence: 99%

Supramolecular Drug Delivery Systems Based on Water-Soluble Pillar[n]arenes

Gao

et al. 2016

The Chemical Record

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Supramolecular drug delivery systems (SDDSs), including various kinds of nanostructures that are assembled by reversible noncovalent interactions, have attracted considerable attention as ideal drug carriers owing to their fascinating ability to undergo dynamic switching of structure, morphology, and function in response to various external stimuli, which provides a flexible and robust platform for designing and developing functional and smart supramolecular nano-drug carriers. Pillar[n]arenes represent a new generation of macrocyclic hosts, which have unique structures and excellent properties in host-guest chemistry. This account describes recent progress in our group to develop pillararene-based stimuli-responsive supramolecular nanostructures constructed by reversible host-guest interactions for controllable anticancer drug delivery. The potential applications of these supramolecular drug carriers in cancer treatment and the fundamental questions facing SDDSs are also discussed.

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Section: Pillararene-based Stimuli-responsive Sddss For Chemo-photodymentioning

confidence: 99%

Supramolecular Drug Delivery Systems Based on Water-Soluble Pillar[n]arenes

Gao

et al. 2016

The Chemical Record

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“…In this construct, watersoluble pillar [5]arene was used as a host (carrier) for a diiodo-BODIPY derivative that contains a quaternary ammonium tail. [25] Supramolecular vesicles (pseudorotaxane) formed with pillar [5]arene and the modified dye are highly stable under physiological conditions but undergo disassembly in an acidic environment to release the dye. In a proof of principle study, the vesicles were found to be cytotoxic only to A549 cancer cells under 690 nm irradiation, suggesting that they disassemble Adv.…”

Section: Low Ph Of Tumor Microenvironments Activates Cancerspecific Imentioning

confidence: 99%

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Kölemen

Yoon

et al. 2016

Adv Funct Materials

427

325

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Recent developments in the design of bifunctional and activatable photo sensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that can serve as potential photosensitizers, the most promising results have come from studies aimed at gaining precise control over the location and rate of cytotoxic singlet oxygen generation. As a consequence, higher selectivities and efficiencies in photodynamic treatment protocols are now within reach. This feature article highlights the variety of approaches that have been pur sued to improve photodynamic therapy and to transform simple photosensi tizers into smarter theranostic agents.

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“…Noncovalent interactions can also endow nanomaterials with tumor‐specific sensitivity and controllable photoactivity . Meng et al developed supramolecular vesicles by using a BODIPY‐functionalized quaternary ammonium derivative (guest) with a water‐soluble pillar[5] arene (WP5, host) ( Figure a,b) . The binding affinity for such a supramolecular system (WP5⊃G) was mainly driven by the cooperative electrostatic and hydrophobic interactions.…”

Section: Bodipy Nano‐photosensitizers For Pdtmentioning

confidence: 99%

“…c) Vesicles and DOX‐loaded vesicles against A549 cancer cells upon irradiation (l = 690 nm, 1.5 J cm −2 ) and in the dark, respectively. All panels reproduced with permission . Copyright 2015, The Royal Society of Chemistry.…”

Section: Bodipy Nano‐photosensitizers For Pdtmentioning

confidence: 99%

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

Sun

Zhao

Fan

et al. 2019

Small

149

116

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As traditional phototherapy agents, boron dipyrromethene (BODIPY) photosensitizers have attracted increasing attention due to their high molar extinction coefficients, high phototherapy efficacy, and excellent photostability. After being formed into nanostructures, BODIPY‐containing nano‐photosensitizers show enhanced water solubility and biocompatibility as well as efficient tumor accumulation compared to BODIPY molecules. Hence, BODIPY nano‐photosensitizers demonstrate a promising potential for fighting cancer. This review contains three sections, classifying photodynamic therapy (PDT), photothermal therapy (PTT), and the combination of PDT and PTT based on BODIPY nano‐photosensitizers. It summarizes various BODIPY nano‐photosensitizers, which are prepared via different approaches including molecular precipitation, supramolecular interactions, and polymer encapsulation. In each section, the design strategies and working principles of these BODIPY nano‐photosensitizers are highlighted. In addition, the detailed in vitro and in vivo applications of these recently developed nano‐photosensitizers are discussed together with future challenges in this field, highlighting the potential of these promising nanoagents for new tumor phototherapies.

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pH-Responsive supramolecular vesicles assembled by water-soluble pillar[5]arene and a BODIPY photosensitizer for chemo-photodynamic dual therapy

Cited by 127 publications

References 48 publications

Supramolecular Drug Delivery Systems Based on Water-Soluble Pillar[n]arenes

Supramolecular Drug Delivery Systems Based on Water-Soluble Pillar[n]arenes

Activatable Photosensitizers: Agents for Selective Photodynamic Therapy

Boron Dipyrromethene Nano‐Photosensitizers for Anticancer Phototherapies

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