pH-responsive scaffolds generate a pro-healing response

You, Jin-Oh; Rafat, Marjan; Almeda, Dariela; Maldonado, Natalia; Guo, Peng; Nabzdyk, Christoph S.; Chun, Maggie; LoGerfo, Frank W.; Hutchinson, John W.; Pradhan-Nabzdyk, Leena; Auguste, Debra T.

doi:10.1016/j.biomaterials.2015.04.011

Cited by 33 publications

(23 citation statements)

References 45 publications

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“…The swelling capacity of the examined hydrogels is, similar to the mechanical properties, dependent on the amount and the strength of the ionizable groups incorporated into the polymer network. The driving force of the osmotic pressure is the reduction of electrostatic repulsions between positively charged amino groups …”

Section: Discussionmentioning

confidence: 99%

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Alkaline poly(ethylene glycol)‐based hydrogels for a potential use as bioactive wound dressings

Koehler

Hedtrich

Brandl

et al. 2017

J Biomedical Materials Res

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The number of patients with chronic wounds is increasing constantly in today's aging society. However, little work is done so far tackling the associated disadvantageous shift of the wound pH. In our study, we developed two different approaches on pH-modulating wound dressing materials, namely, bioactive interpenetrating polymer network hydrogels based on poly(ethylene glycol) diacrylate/N-vinylimidazole/alginate (named VI ) and poly(ethylene glycol) diacrylate/2-dimethylaminoethyl methacrylate/N-carboxyethylchitosan (named DMAEMA ). Both formulations showed a good cytocompatibility and wound healing capacity in vitro. The developed dressing materials significantly increased the cell ingrowth in wounded human skin constructs; by 364% and 313% for the VI and the DMAEMA hydrogel formulation, respectively. Additionally, VI hydrogels were found to be suitable scaffolds for superficial cell attachment. Our research on the material properties suggests that ionic interactions and hydrogen bonds are the driving forces for the mechanical and swelling properties of the examined hydrogels. High amounts of positively charged amino groups in DMAEMA hydrogels caused increased liquid uptake (around 190%), whereas VI hydrogels showed a 10-fold higher maximum compressive stress in comparison to hydrogels without ionizable functional groups. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3360-3368, 2017.

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Section: Discussionmentioning

confidence: 99%

“…The driving force of the osmotic pressure is the reduction of electrostatic repulsions between positively charged amino groups. 39 The incorporated amount of ammonium groups (CEC < VI < DMAEMA) also drives the acid neutralizing capacity, which was the far largest for DMAEMA 2.0 hydrogels. Again, no desired value might be given.…”

Section: Discussionmentioning

confidence: 99%

Alkaline poly(ethylene glycol)‐based hydrogels for a potential use as bioactive wound dressings

Koehler

Hedtrich

Brandl

et al. 2017

J Biomedical Materials Res

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“…The studied scaffold showed the capacity to expand to low pH stimuli, thus, enhancing nutrient and oxygen transport to alter the local cell density. Moreover, this approach improved wound healing in vivo by enhancing angiogenesis and inducing the expression of pro‐healing genes …”

Section: The Bio‐relevance Of Nanobiomaterials Surface Modificationsmentioning

confidence: 99%

Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine

Rana

Ramasamy

Leena

et al. 2016

Biotechnology Progress

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Stem cell-based approaches offer great application potential in tissue engineering and regenerative medicine owing to their ability of sensing the microenvironment and respond accordingly (dynamic behavior). Recently, the combination of nanobiomaterials with stem cells has paved a great way for further exploration. Nanobiomaterials with engineered surfaces could mimic the native microenvironment to which the seeded stem cells could adhere and migrate. Surface functionalized nanobiomaterial-based scaffolds could then be used to regulate or control the cellular functions to culture stem cells and regenerate damaged tissues or organs. Therefore, controlling the interactions between nanobiomaterials and stem cells is a critical factor. However, surface functionalization or modification techniques has provided an alternative approach for tailoring the nanobiomaterials surface in accordance to the physiological surrounding of a living cells; thereby, enhancing the structural and functional properties of the engineered tissues and organs. Currently, there are a variety of methods and technologies available to modify the surface of biomaterials according to the specific cell or tissue properties to be regenerated. This review highlights the trends in surface modification techniques for nanobiomaterials and the biological relevance in stem cell-based tissue engineering and regenerative medicine. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:554-567, 2016.

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“…In the past, bioinert materials were often chosen for developing strategies for tissue regeneration, as they presumably avoided undesirable host responses. In more recent years, however, the paradigm shifted towards the use of biointeractive, dynamic systems able to either induce particular cellular responses [27][28][29] (i.e., cell instructive) and/or be themselves modulated by cells [30,31] (i.e., cell responsive) or the surrounding environment [32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

et al. 2020

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Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.

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pH-responsive scaffolds generate a pro-healing response

Cited by 33 publications

References 45 publications

Alkaline poly(ethylene glycol)‐based hydrogels for a potential use as bioactive wound dressings

Alkaline poly(ethylene glycol)‐based hydrogels for a potential use as bioactive wound dressings

Surface functionalization of nanobiomaterials for application in stem cell culture, tissue engineering, and regenerative medicine

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

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