pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release

Advances in PEG-based ABC terpolymers and their applications

“…6). 89 TPE-2OH, an aggregation-induced emission (AIE) characteristic luminogen, was mainly distributed in the interlayer between the core and the shell of polymeric micelles. If pH decreased to 6.5 or lower, amino of PEG-b-PEI-b-PCL was protonated, resulting in the disassociation of hydrogenbonding.…”

“…Fig.6pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release prepared from ABC linear terpolymers. Reprinted with permission 89. Copyright (2019) Springer.…”

Light-Activated Nanodevice for On-Demand Imaging of miRNA in Living Cells via Logic Assembly

“…In recent years, there has been increasing evidence that miRNAs are associated with human diseases and that aberrant miRNA expression can be detected in almost all types of tumors, such as lung, cervical, and breast cancers. , Some studies have reported that miRNAs have simpler structures and less postsynthesis processing than proteins and DNA, making them better choices both as biomarkers for disease diagnosis and prognosis and as potential therapeutic targets for the disease. , Sensitive imaging of intracellular miRNAs in cells is of great importance in clinical diagnosis and disease treatment, and there is growing evidence that sequence-specific miRNAs with abnormal expression levels are associated with the development and progression of cancer and other diseases. − Therefore, miRNAs have emerged as promising biomarkers for the early diagnosis and treatment of tumors. The major limitation of intracellular miRNA imaging analysis is that the “always active” systems are turned on by binding to the extracellular target before it reaches the desired location within the cell, resulting in poor detection accuracy and a low signal-to-noise ratio. − Therefore, developing a method to track and image intracellular miRNAs for “on-demand” accurate detection in both temporal and spatial dimensions remains an important challenge. , Various physiological stimuli, including pH, temperature, enzymatic action, and redox, have been used to construct stimulus-responsive miRNA detection sensors. − However, the low expression of miRNAs and the complex environment in cells pose a great challenge to monitor and track miRNAs in vivo.…”