pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release

Dai, Yu; Wu, Dengjin; Lin, Shuo; Ma, Xin; Zhang, Xiaojin; Xia, Fan

doi:10.1007/s11051-018-4447-4

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…Micelles are structurally unstable, which restricts their practical applications. Physiological factors like dilution in body fluids, ionic strength, pH, and temperature make the micelles prone to destruction 129 . A helpful method for improving stability is to crosslink the micelle core using a bi‐functional crosslinker through a chemical reaction of functional groups of polymer chains.…”

Section: Classification Of Ph‐responsive Polymersmentioning

confidence: 99%

“…Physiological factors like dilution in body fluids, ionic strength, pH, and temperature make the micelles prone to destruction. 129 A helpful method for improving stability is to crosslink the micelle core using a bi-functional crosslinker through a chemical reaction of functional groups of polymer chains. Polymer micelles have a narrow size range, with diameters ranging from 10 to 100 nm.…”

Section: Ph-responsive Micellesmentioning

confidence: 99%

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pH‐responsive polymers for drug delivery: Trends and opportunities

Singh,

Nayak

2023

Journal of Polymer Science

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Polymer science has applications in biomedical engineering, prosthetics, surgical implants, and prospective pharmaceutical excipients for drug delivery. “Intelligent or Smart Polymers” are created for drug targeting either by derivatization of natural polymers or controlled radical polymerization of electrolytes. Their mode of action is governed by the environmental stimuli viz. temperature, pH, ionic concentration, magnetism, and so on. pH‐responsive polymers, because of their self‐assembling behavior, alter their solubility, conformation, surface activity, and hydrophilicity when exposed to a specific pH. The physiological pH varies from acidic nuclei to alkaline cytoplasm and highly acidic gastric juice to slightly alkaline plasma; thus, various polymers are under study for delivering small molecules, genes, peptides, enzymes, growth factors, and antibodies. The non‐invasive drug delivery routes like oral, ocular, nasal, pulmonary, transdermal, and rectal routes can be explored for targeting recombinant proteins, monoclonal antibodies, and small molecules with particular emphasis on the individual's physiological and pathological state. Further, these polymers can be designed into various architectures like dendrimers, liposomes, micelles, and metallic nanoparticles that can serve as drug reservoirs for sustaining drug release. The challenges in this field are the selection of biocompatible polymers with ease of synthesis and scale‐up, ensuring effective drug‐loading, and stability aspects, producing robust pharmacological data, and timely regulatory approvals. This review exclusively explores the physicochemical characteristics of pH‐responsive polymers, their categorization, various architectural entities, recent studies and patents, and their emerging applications concerning specific diseases.

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Section: Classification Of Ph‐responsive Polymersmentioning

confidence: 99%

Section: Ph-responsive Micellesmentioning

confidence: 99%

pH‐responsive polymers for drug delivery: Trends and opportunities

Singh,

Nayak

2023

Journal of Polymer Science

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“…6). 89 TPE-2OH, an aggregation-induced emission (AIE) characteristic luminogen, was mainly distributed in the interlayer between the core and the shell of polymeric micelles. If pH decreased to 6.5 or lower, amino of PEG-b-PEI-b-PCL was protonated, resulting in the disassociation of hydrogenbonding.…”

Section: Applicationsmentioning

confidence: 99%

“…Fig.6pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release prepared from ABC linear terpolymers. Reprinted with permission 89. Copyright (2019) Springer.…”

mentioning

confidence: 99%

Advances in PEG-based ABC terpolymers and their applications

Zhang

Dai

et al. 2020

RSC Adv.

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“…In recent years, there has been increasing evidence that miRNAs are associated with human diseases and that aberrant miRNA expression can be detected in almost all types of tumors, such as lung, cervical, and breast cancers. , Some studies have reported that miRNAs have simpler structures and less postsynthesis processing than proteins and DNA, making them better choices both as biomarkers for disease diagnosis and prognosis and as potential therapeutic targets for the disease. , Sensitive imaging of intracellular miRNAs in cells is of great importance in clinical diagnosis and disease treatment, and there is growing evidence that sequence-specific miRNAs with abnormal expression levels are associated with the development and progression of cancer and other diseases. − Therefore, miRNAs have emerged as promising biomarkers for the early diagnosis and treatment of tumors. The major limitation of intracellular miRNA imaging analysis is that the “always active” systems are turned on by binding to the extracellular target before it reaches the desired location within the cell, resulting in poor detection accuracy and a low signal-to-noise ratio. − Therefore, developing a method to track and image intracellular miRNAs for “on-demand” accurate detection in both temporal and spatial dimensions remains an important challenge. , Various physiological stimuli, including pH, temperature, enzymatic action, and redox, have been used to construct stimulus-responsive miRNA detection sensors. − However, the low expression of miRNAs and the complex environment in cells pose a great challenge to monitor and track miRNAs in vivo.…”

Section: Introductionmentioning

confidence: 99%

Light-Activated Nanodevice for On-Demand Imaging of miRNA in Living Cells via Logic Assembly

Zhou

Jiang

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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Low-abundance biomarker amplification detection systems have been widely used to detect miRNAs; however, "always active" systems are insufficient for high spatial and temporal control of miRNAs. Here, we constructed a light-activated nanodevice (LAN) based on DNA nanotechnology for high spatial and temporal precision detection of low-abundance miRNA. Light-activated hairpin probes and triple-helix molecular switches were modified on the surface of gold nanoparticles (AuNPs) to trigger miRNA on-demand imaging analysis by UV light activation. In the presence of both UV light and miRNA, the LAN releases hairpin DNA and completes the hybridization chain reaction (HCR) with the conformation-altered triple-helix molecular switch, enabling fluorescence imaging of low-abundance miRNAs in living cells. The current work provides an opportunity to develop light-activated signal amplification sensors that can accurately image miRNAs on-demand in both temporal and spatial dimensions.

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pH-responsive polymeric micelles with tunable aggregation-induced emission and controllable drug release

Cited by 11 publications

References 34 publications

pH‐responsive polymers for drug delivery: Trends and opportunities

pH‐responsive polymers for drug delivery: Trends and opportunities

Advances in PEG-based ABC terpolymers and their applications

Light-Activated Nanodevice for On-Demand Imaging of miRNA in Living Cells via Logic Assembly

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