2007
DOI: 10.1016/j.chemphyslip.2007.06.069
View full text
|
Sign up to set email alerts
|
Share

Abstract: Duramycin is a 19 amino acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids (PE and ethanolamine plasmalogen). Model membrane study indicates that the binding of duramycin and cinnamycin to PE-containing liposomes is dependent on membrane curvature, i.e., the lantibiotics b…

Expand abstract