2015
DOI: 10.18632/aging.100790
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Has erratum 2016-4-23Has erratum 2015-9-4
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Abstract: Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative disorders. PGC1α exerts its neuroprotective effects by promoting mitochondrial biogenesis (MB) and functioning. However, the precise regulatory role of PGC1α in the control of mitochondrial dynamics (MD) and neurotoxicity is still unknown. Here we elucidate the role of PGC1α in vitro and in vivo in the regulatory context of MB and MD in response to lead (II) acetate as a relevant mo… Show more

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Cited by 68 publications
(44 citation statements)
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References 37 publications
(44 reference statements)
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“…Secondly, deposition of fibrillin-1 protein is enhanced by THs, along with a marked improvement in the overall structure of fibrillin-rich microfibrils in the papillary dermis (Supplementary Figure S4), similar to the effects reported for other candidate human skin anti-aging agents (Watson et al, 2001;2008;2014). Thirdly, T 4 down-regulated the senescence marker p16 ink4 , while T 3 up-regulated the gene expression of both, sirt1 and PGC1α on the mRNA and protein level, two key regulators of cellular oxidative stress, aging and mitochondrial function (Austin and StPierre, 2012;Baker et al, 2011;Dabrowska et al, 2015;Geng et al, 2010).…”
Section: Discussionsupporting
confidence: 77%
See 1 more Smart Citation
“…Secondly, deposition of fibrillin-1 protein is enhanced by THs, along with a marked improvement in the overall structure of fibrillin-rich microfibrils in the papillary dermis (Supplementary Figure S4), similar to the effects reported for other candidate human skin anti-aging agents (Watson et al, 2001;2008;2014). Thirdly, T 4 down-regulated the senescence marker p16 ink4 , while T 3 up-regulated the gene expression of both, sirt1 and PGC1α on the mRNA and protein level, two key regulators of cellular oxidative stress, aging and mitochondrial function (Austin and StPierre, 2012;Baker et al, 2011;Dabrowska et al, 2015;Geng et al, 2010).…”
Section: Discussionsupporting
confidence: 77%
“…in organ-cultured human skin under serum-and TH-free conditions. First, we investigated the expression of mitochondrially encoded cytochrome c oxidase I (MTCO1), the mitochondrial transcription factor A (TFAM), which controls mitochondrial biogenesis and mitochondrial DNA synthesis (Baris et al, 2011;Campbell et al, 2012;Kloepper et al, 2015;Shutt et al, 2011), and the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), a key transcription factor that regulates mitochondrial biogenesis and numerous other cell functions including aging, whose reduction in activity has an aging-promoting effect (Dabrowska et al, 2015;Gilbert, 2013;Riera and Dillin, 2015). To assess whether any expression changes in these parameters altered also the intraepidermal mitochondrial oxidative phosphorylation, we asked whether THs modified the activity of complex I, the initial step of the mitochondrial respiratory chain (Chandel and Jeffs, 2015;Hirst, 2013;Scheffler, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…The apoptotic disassembly of motor neurons could begin regionally near dysfunctional mitochondria and spread to a wider area, resulting in motor neuronal death. Our speculation is supported from data that show that in aging-associated neural diseases, there is a loss of mitochondrial function leading to increased mPTP sensitivity, and attenuated mitophagy that contributes to apoptosis (32, 68, 86, 99, 111). Nevertheless, we do not have data to support a process of aging associated localized motor neuron disassembly outside of neural degenerative disease.…”
Section: Local Apoptotic Signaling In Aging Muscles and Motor Neuronsmentioning
confidence: 55%
“…We also observed an increase in both the gene transcript and protein levels of PGC1α. PGC1α mRNA increases in response to acute metabolic stressors [40] and has been shown in a number of studies to regulate mechanisms that mediate mitochondrial dynamics [41, 42]. …”
Section: Discussionmentioning
confidence: 99%