Abstract:Background:Mutations in cohesin complex genes have been described commonly in several types of cancer, with an incidence of 8% in myeloid diseases and myelodysplastic syndromes (MDS), and have been linked to marrow fibrosis by our group in a prior publication (Ramos F et al. Oncotarget 2016). However, their clinical impact is still undetermined.Aims:To identify mutations in cohesin complex genes in MDS patients by next generation sequencing (NGS) and to analyze their implications at clinical level (correlation… Show more
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