PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder

He, Xiao; Jin, Chentao; Ma, Mindi; Zhou, Rui; Wu, Shuang; Huang, Haoying; Li, Yuting; Chen, Qiaozhen; Zhang, Ming‐Rong; Zhang, Hong; Tian, Mei

doi:10.1007/s11684-019-0704-x

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…We adopted two independent t -tests to evaluate regional metabolic differences between baseline and post-stimulation PET images. Statistical significance was determined when p value < 0.01 and cluster Ke > 100 [ 10 ]. The lesion-to-normal (L/N) ratio was used for semi-quantitative analysis by using PMOD (v.3.902, PMOD Technologies Ltd.).…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model

Wang

et al. 2022

Eur J Nucl Med Mol Imaging

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Purpose Toothache, a common disorder afflicting most people, shows distinct features at different clinical stages. This study aimed to depict metabolic changes in brain and investigate the potential mechanism involved in the aberrant affective behaviors during the natural process of toothache. Methods We investigated the spatiotemporal patterns of brain function during the natural course of toothache in a rat model of dental pulp injury (DPI) by using positron emission tomography (PET). Results Glucose metabolism peaked on the 3rd day and gradually decreased in several brain regions after DPI, which was in line with the behavioral and histological results. PET imaging showed that visual pathway was involved in the regulation of toothache. Meanwhile, the process of emotional regulation underlying toothache was mediated by N-methyl-D-aspartic receptor subunit 2B (NR2B) in the caudal anterior cingulate cortex (cACC). Conclusion Our results revealed the spatiotemporal neurofunctional patterns during toothache process and preliminarily elucidated the role of NR2B in cACC in the regulation of toothache-related affective behaviors.

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Section: Methodsmentioning

confidence: 99%

Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model

Wang

et al. 2022

Eur J Nucl Med Mol Imaging

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“…We adopted two independent t-tests to evaluate regional metabolic differences between baseline and post-stimulation PET images. Statistical signi cance was determined when P value < 0.01 and cluster Ke > 100 [10]. The lesion-to-normal (L/N) ratio was used for semi-quantitative analysis by using PMOD (v.3.902, PMOD Technologies Ltd.).…”

Section: Pet Imaging and Image Analysismentioning

confidence: 99%

Spatiotemporal Dynamics of Brain Function During the Natural Course in a Dental Pulp Injury Model

Wang

et al. 2021

Preprint

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Purpose Toothache, a common disorder afflicting most people, shows distinct features at different clinical stages. This study aimed to depict metabolic changes in brain and investigate the potential mechanism involved in the aberrant affective behaviors during the natural process of toothache. Methods We investigated the spatiotemporal patterns of brain function during the natural course of toothache in a rat model of dental pulp injury (DPI) by using positron emission tomography (PET). Results Glucose metabolism peaked on the 3rd day and gradually decreased in several brain regions after DPI, which was in line with the behavioral and histological results. PET imaging showed visual pathway was involved in the regulation of toothache. Meanwhile, the process of emotional regulation underlying toothache was mediated by N-methyl-D-aspartic receptor subunit 2B (NR2B) in the caudal anterior cingulate cortex (cACC). Conclusion Our results revealed the spatiotemporal neurofunctional patterns during toothache process and preliminarily elucidated the role of NR2B in cACC in the regulation of toothache-related affective behaviors.

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“…A novel tool towards this goal is the combination of neuromodulation techniques with whole-brain functional neuroimaging to characterize regional activity both locally and distally [2]. Several studies have been already produced combining invasive modulation techniques such as deep brain stimulation (DBS), optogenetic stimulation and chemogenetics, as well as non-invasive ones like focused ultrasound stimulation (FUS) and transcranial direct current stimulation (TDCS), with functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), showing that this approach is highly promising [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. However, within the invasive techniques, lack of cell-type and spatial specificity, together with the development of scar tissue around chronic implants and complications arising from parasitic Joule heating are well-known issues with electrical stimulation [14].…”

Section: Introductionmentioning

confidence: 99%

Mapping whole brain effects of infrared neural stimulation with positron emission tomography

Meneghetti

Gudmundsen

Jessen³

et al. 2022

Preprint

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The combination of neuroimaging and targeted neuromodulation is a crucial tool to gain a deeper understanding of neural networks at a circuit level. Infrared neurostimulation (INS) is a promising optical modality that allows to evoke neuronal activity with high spatial resolution without need for the introduction of exogenous substances in the brain. Here, we report the use of whole-brain functional [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) imaging during INS in the dorsal striatum, performed using a multifunctional soft neural probe. We demonstrate the possibility to identify multi-circuit connection patterns in both cortical and subcortical brain regions within a single scan. By using a bolus plus infusion FDG-PET scanning protocol, we were able to observe the metabolic rate evolution in these regions during the experiments and correlate its variation with the onset of the INS stimulus. Due to the focality of INS and the large amount of viable molecular targets for PET, this novel approach to simultaneous imaging and stimulation is highly versatile. This pilot study can pave the way to further understand the brain connectivity on a global scale.

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PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder

Cited by 6 publications

References 38 publications

Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model

Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model

Spatiotemporal Dynamics of Brain Function During the Natural Course in a Dental Pulp Injury Model

Mapping whole brain effects of infrared neural stimulation with positron emission tomography

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