PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome

Marchal, G; Rioux, Patrice; Petit-Tabou, M.C.; Derlon, Jean-Michel; Baron, Jean‐Claude; Serrati, Carlo; Viader, Fausto; Sayette, Vincent de La; Doze, F. Le; Lochon, P.; Petit-Taboué, M.C.; Orgogozo, J. M.

doi:10.1016/0140-6736(93)91214-7

Cited by 205 publications

(123 citation statements)

References 6 publications

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“…It seems obvious that the decrease in CBF corresponds to those observed in laser Doppler flowmetry, positron emission tomography, and perfusion-weighted magnetic resonance imaging studies of stroke. 13,[32][33][34][35][36] The persistent reduction in neuronal IM might be related with decreases in the cerebral metabolic rate for oxygen and glucose measured by positron emission tomography in stroke patients. [33][34][35] Also, the reduced IM is of immediate relevance in quantifying the nature of changes in cellular dynamics revealed by diffusion-weighted magnetic resonance imaging in human studies of stroke.…”

Section: Discussionmentioning

confidence: 99%

“…13,[32][33][34][35][36] The persistent reduction in neuronal IM might be related with decreases in the cerebral metabolic rate for oxygen and glucose measured by positron emission tomography in stroke patients. [33][34][35] Also, the reduced IM is of immediate relevance in quantifying the nature of changes in cellular dynamics revealed by diffusion-weighted magnetic resonance imaging in human studies of stroke. [36][37][38][39] For instance, our observation of a decrease in IM of organelles is closely related to the decrease in diffusion of metabolites during and immediately after ischemic stroke, as observed by diffusionweighted magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

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Quantitative Imaging of Cerebral Blood Flow Velocity and Intracellular Motility using Dynamic Light Scattering–Optical Coherence Tomography

Lee

Radhakrishnan

et al. 2013

J Cereb Blood Flow Metab

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This paper describes a novel optical method for label-free quantitative imaging of cerebral blood flow (CBF) and intracellular motility (IM) in the rodent cerebral cortex. This method is based on a technique that integrates dynamic light scattering (DLS) and optical coherence tomography (OCT), named DLS-OCT. The technique measures both the axial and transverse velocities of CBF, whereas conventional Doppler OCT measures only the axial one. In addition, the technique produces a three-dimensional map of the diffusion coefficient quantifying nontranslational motions. In the DLS-OCT diffusion map, we observed high-diffusion spots, whose locations highly correspond to neuronal cell bodies and whose diffusion coefficient agreed with that of the motion of intracellular organelles reported in vitro in the literature. Therefore, the present method has enabled, for the first time to our knowledge, label-free imaging of the diffusion-like motion of intracellular organelles in vivo. As an example application, we used the method to monitor CBF and IM during a brief ischemic stroke, where we observed an induced persistent reduction in IM despite the recovery of CBF after stroke. This result supports that the IM measured in this study represent the cellular energy metabolism-related active motion of intracellular organelles rather than free diffusion of intracellular macromolecules.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quantitative Imaging of Cerebral Blood Flow Velocity and Intracellular Motility using Dynamic Light Scattering–Optical Coherence Tomography

Lee

Radhakrishnan

et al. 2013

J Cereb Blood Flow Metab

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“…[1][2][3][4] Hypoxia/ischemia-induced angiogenesis is a tightly controlled multistep process by which new blood vessels are formed by sprouting from the pre-existing vasculature. 5 The induction of angiogenesis after cerebral ischemia could be interpreted as a natural defense mechanism helping to restore oxygen and nutrient supply in the respective tissue.…”

mentioning

confidence: 99%

Expression of Angiopoietin-1, Angiopoietin-2, and Tie Receptors after Middle Cerebral Artery Occlusion in the Rat

Beck

Acker

Wiessner

et al. 2000

The American Journal of Pathology

187

141

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“…It was hoped that the same hypothesis would be valid in stroke, because most strokes are due to either large or small vessel atherothrombosis. Prospective analysis of spontaneous reperfusion rates in patients with stroke suggests early reperfusion of viable tissue is associated with smaller infarcts and a better prognosis (22). Initial thrombolytic work in animals was promising, but the Jiical studies conducted since have failed to present a conclusive case for the use of thrombolytics in ischaemic stroke.…”

Section: Thrombolysismentioning

confidence: 99%

The rationale for new therapies in acute ischaemic stroke

Dyker

Lees

1996

Journal of Clinical Pharmacy and Therapeutics

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Summary Although stroke is a major cause of morbidity and mortality, it is only relatively recently that a concerted effort has been made to develop acute treatments. Thrombolytics, such as recombinant tissue plasminogen activator (rt‐PA), may benefit selected patients within 3 h of cerebral infarction. Currently, rt‐PA is only licensed for use in the United States. Many potential strategies for neuroprotection exist and are currently under investigation. Because the mechanisms of neurotoxicity involve numerous interdependent processes, it may be that interruption of a single site in the cascade of events is insufficient to provide effective neuroprotection. Drugs acting at several sites in the neurotoxic cascade may be more effective, and the results of Phase III studies with the novel neuroprotectant lubeluzole are anticipated.

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PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome

Cited by 205 publications

References 6 publications

Quantitative Imaging of Cerebral Blood Flow Velocity and Intracellular Motility using Dynamic Light Scattering–Optical Coherence Tomography

Quantitative Imaging of Cerebral Blood Flow Velocity and Intracellular Motility using Dynamic Light Scattering–Optical Coherence Tomography

Expression of Angiopoietin-1, Angiopoietin-2, and Tie Receptors after Middle Cerebral Artery Occlusion in the Rat

The rationale for new therapies in acute ischaemic stroke

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