PET/CT image fusion error due to urinary bladder filling changes: consequence and correction

Heiba, Sherif; Raphael, Barbara; Castellon, Ivan; Altinyay, Erkan; Sandella, Nick; Rosen, Gerald; Abdel‐Dayem, Hussein M.

doi:10.1007/s12149-009-0304-y

Cited by 9 publications

(4 citation statements)

References 6 publications

(9 reference statements)

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“…After the segmentation, the bladder was analytically projected with the same projector that was used for the iterative reconstruction, generating new analytical sinograms of the bladder only. Segmenting directly from a fused CT image would avoid the step of the first reconstruction, but since the bladder volume will vary during the acquisition, and as PET and CT acquisitions are not simultaneous, there will be a size mismatching between CT and PET, making the PET segmentation more convenient for the particular case of the bladder (Heiba et al 2009). This limitation may be diminished if simultaneous PET-MR systems are utilised, where the bladder could be accurately segmented from the MR co-registered image.…”

Section: Discussionmentioning

confidence: 99%

Impact and correction of the bladder uptake on¹⁸F-FCH PET quantification: a simulation study using the XCAT2 phantom

et al. 2016

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The spill-in counts from neighbouring regions can significantly bias the quantification over small regions close to high activity extended sources. This effect can be a drawback for 18 F-based radiotracers positron emission tomography (PET) when quantitatively evaluating the bladder area for diseases such as prostate cancer. In this work, we use Monte Carlo simulations to investigate the impact of the spill-in counts from the bladder on the quantitative evaluation of prostate cancer when using 18 F-Fluorcholine (FCH) PET and we propose a novel reconstruction-based correction method. Monte Carlo simulations of a modified version of the XCAT2 anthropomorphic

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Section: Discussionmentioning

confidence: 99%

Impact and correction of the bladder uptake on¹⁸F-FCH PET quantification: a simulation study using the XCAT2 phantom

et al. 2016

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“…Heiba et al (31), in reviewing integrated PET/CT images, observed considerable variation in the shape of the urinary bladder between the CT and PET scans and reported that this error can be significantly minimized by repeating the PET and CT scans of the pelvis in a single bed within a short period of one another. We did not observe any problem related to coregistration, even in a patient with a false-positive result (Fig.…”

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confidence: 99%

Impact of 18F-FDG PET/CT with Retrograde Filling of the Urinary Bladder in Patients with Suspected Pelvic Malignancies

Vicente

Castrejón²,

Muñoz³

et al. 2010

Journal of Nuclear Medicine Technology

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The purpose of this study was to assess the feasibility of selective pelvic PET/CT with retrograde bladder irrigation in evaluating pelvic pathologies. Methods: Thirty-eight patients (22 women and 16 men), with a mean age of 61 y (range, 41-81 y) and a neoplastic background (most of them of pelvic pathology), were assessed with PET/CT. The most prevalent findings were urothelial (14 cases), gynecologic (12 cases), and rectal (7 cases) cancers. All but 3 patients had undergone previous surgical procedures or radio-or chemotherapy. Twenty-two patients had suspected pelvic pathology on a previous diagnostic CT scan. All the patients underwent a standard PET/CT protocol (from head to upper thighs) 60 min after the intravenous injection of 370 MBq of 18 F-FDG. Additional delayed pelvic PET/CT images were acquired with a filled-bladder technique. Both series of images were assessed by 2 experienced observers. A lesion was classified as malignant if it showed a standardized uptake value greater than 2.5 or, in the case of subcentimetric lesions, any uptake greater than background activity that persisted or increased on delayed pelvic imaging. All lesions were evaluated histologically or by clinical follow-up. Results: Twenty-seven of 43 studies were categorized as pathologic using PET/CT. Nineteen studies showed abnormalities in the pelvis; the findings of 5 of these studies were false-positive. Ten studies showed pathologic 18 F-FDG uptake in the bladder wall; in 7 of these studies the uptake was found to be true-positive on histopathologic examination. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET/CT in the pelvic assessment were 100%, 83%, 74%, 100%, and 76%, respectively. The retrograde filling reduced the interference with physiologic urinary accumulation of 18 F-FDG in patients with possible pelvic lesions; no false-negative results were documented. Conclusion: In 18 F-FDG PET studies, retrograde filling of the urinary bladder is recommended to assess bladder wall lesions and malignancies in other pelvic locations. Several investigators have considered 18 F-FDG PET of no utility in the detection of kidney, ureter, bladder, and prostate tumors (1-7). Because 18 F-FDG is not reabsorbed as glucose, the limitation of 18 F-FDG PET has been attributed to glomerular filtration and urinary excretion (8). Furthermore, high 18 F-FDG activity in the urinary bladder is especially a problem in the evaluation of gynecologic tumors.On the other hand, previous treatments or diagnostic procedures such as biopsy, radiotherapy, systemic chemotherapy, and intravesical agents (e.g., bacille CalmetteGuérin) can cause circumferential bladder wall thickening, mimicking bladder cancer (9). The pooled activity in the urinary bladder makes the evaluation of these bladder wall lesions difficult or even impossible.Several methods have been used in an attempt to palliate this situation, with controversial results. Some approaches based on the continuous or not continuous irrigation of ...

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“…Fluids constantly move within the body. This manifests in a likely expansion of the bladder [ 13 ], but also in a change of stomach and intestine locations [ 14 ]. Thus, imaging the bladder, the stomach, the intestines and their surroundings can pose additional challenges [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic motion compensation strategies for positron emission tomography when acquired simultaneously with magnetic resonance imaging

Polycarpou

Soultanidis

Tsoumpas

2021

Phil. Trans. R. Soc. A.

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Subject motion in positron emission tomography (PET) is a key factor that degrades image resolution and quality, limiting its potential capabilities. Correcting for it is complicated due to the lack of sufficient measured PET data from each position. This poses a significant barrier in calculating the amount of motion occurring during a scan. Motion correction can be implemented at different stages of data processing either during or after image reconstruction, and once applied accurately can substantially improve image quality and information accuracy. With the development of integrated PET-MRI (magnetic resonance imaging) scanners, internal organ motion can be measured concurrently with both PET and MRI. In this review paper, we explore the synergistic use of PET and MRI data to correct for any motion that affects the PET images. Different types of motion that can occur during PET-MRI acquisitions are presented and the associated motion detection, estimation and correction methods are reviewed. Finally, some highlights from recent literature in selected human and animal imaging applications are presented and the importance of motion correction for accurate kinetic modelling in dynamic PET-MRI is emphasized. This article is part of the theme issue ‘Synergistic tomographic image reconstruction: part 2’.

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PET/CT image fusion error due to urinary bladder filling changes: consequence and correction

Cited by 9 publications

References 6 publications

Impact and correction of the bladder uptake on¹⁸F-FCH PET quantification: a simulation study using the XCAT2 phantom

Impact and correction of the bladder uptake on¹⁸F-FCH PET quantification: a simulation study using the XCAT2 phantom

Impact of 18F-FDG PET/CT with Retrograde Filling of the Urinary Bladder in Patients with Suspected Pelvic Malignancies

Synergistic motion compensation strategies for positron emission tomography when acquired simultaneously with magnetic resonance imaging

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PET/CT image fusion error due to urinary bladder filling changes: consequence and correction

Cited by 9 publications

References 6 publications

Impact and correction of the bladder uptake on18F-FCH PET quantification: a simulation study using the XCAT2 phantom

Impact and correction of the bladder uptake on18F-FCH PET quantification: a simulation study using the XCAT2 phantom

Impact of 18F-FDG PET/CT with Retrograde Filling of the Urinary Bladder in Patients with Suspected Pelvic Malignancies

Synergistic motion compensation strategies for positron emission tomography when acquired simultaneously with magnetic resonance imaging

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Impact and correction of the bladder uptake on¹⁸F-FCH PET quantification: a simulation study using the XCAT2 phantom

Impact and correction of the bladder uptake on¹⁸F-FCH PET quantification: a simulation study using the XCAT2 phantom