Perturbation of xenobiotic metabolism in Dreissena polymorpha model exposed in situ to surface water (Lake Trasimene) purified with various disinfectants

Sapone, Andrea; Canistro, Donatella; Vivarelli, Fabio; Paolini, Moreno

doi:10.1016/j.chemosphere.2015.09.022

Cited by 21 publications

(11 citation statements)

References 59 publications

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“…Also Guzzella et al [213] observed that PAA decreased the genotoxic load of surface waters. Monarca and D. polymorpha biomarkers and genotoxic DBPs were observed to be excreted in the bile of C. carpio: therefore PAA still remained as potentially co-carcinogenic [216][217][218]. However, no cytotoxic effects or glutathione content variation were determined in rainbow trout hepatocytes after exposure to surface water treated with PAA, but increased reactive oxygen species (ROS) production was observed [219].…”

Section: Ch 3 Coooh + Ch 3 Oh → Ch 3 Cooh + Hcho + H O(14) Ch 3 Cooohmentioning

confidence: 99%

Peracids in water treatment: A critical review

Luukkonen

Pehkonen

2016

Critical Reviews in Environmental Science and Technology

256

122

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Peracids have gained interest in the water treatment over the last few decades. Peracetic acid (CH 3 CO 3 H) has already become an accepted alternative disinfectant in wastewater disinfection whereas performic acid (CHO 3 H) has been studied much less, although it is also already commercially available. Peracids have also been tested for drinking water disinfection, oxidation of aqueous (micro)pollutants, sludge treatment and ballast water treatment, to name just a few examples. The purpose of this review paper is to represent comprehensive up-to-date information about the water treatment applications, aqueous reaction mechanisms, and disinfection byproduct formation of peracids, namely performic, peracetic and perpropionic acids. and PFA have several of the qualities of an ideal disinfectant: toxicity to microorganisms, but not to higher forms of life; effectivity at ambient temperatures; stability and long shelf-life; low corrosivity; deodorizing ability; widespread availability and reasonable cost [12].PAA and PFA are colorless liquids with characteristic pungent odors. Both are thermodynamically unstable and can decompose spontaneously or explode when highly concentrated, heated, under mechanical stress or exposed to catalytic effects of impurities [1,13,14]. The recommended storage temperatures are below 30 and 20°C for PAA and PFA, respectively [6,14]. Longer carbon chain length increases stability, and thus PAA is more stable than PFA [1]. However, the O-O bond dissociation energy of PFA and PAA has been calculated to be similar: 48 kcal/mol [15]. Percarboxylic acids have typically pK a values 3-4 units higher than the parent carboxylic acids [1]. Nonetheless, PFA and PAA are corrosive [16]. ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 3Exposure to PAA and PFA causes irritation and possibly permanent damage to the skin (cutaneous emphysema), eyes and the respiratory system. In the skin contact, 0.2% is proposed as the no-observed-effect concentration (NOEC) for short and medium length exposure [17].When inhaled, airborne concentrations less than 0.16-0.17 ppm (0.50-0.52 mg/m 3 ) are considered to cause no irritation [17,18]. However, higher concentrations are harmful and a case study suggested that PAA could cause occupational asthma [19].The largest users of PAA on a global scale (estimated in 2013) are shown in Fig. 1. Similar numbers are not available for PFA, but it is probably used at significantly lower quantities.The largest user, the food industry, applies PAA as a disinfectant in fresh produce washing water, clean-in-place (CIP) processes, on food processing equipment, and in pasteurizers, to name just a few examples [21,22]. PFA is also a suitable disinfectant in low-temperature refrigerated food processing and storage rooms [23]. In healthcare, PAA is used for instance in Recently, methods to determine the residual PAA from wastewater were compared: the spectrophotometric method using DPD and catalase was recommended for 0.1-0.5 mg/L PAA concentrations and the cerimetric/iodometric titration...

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Section: Ch 3 Coooh + Ch 3 Oh → Ch 3 Cooh + Hcho + H O(14) Ch 3 Cooohmentioning

confidence: 99%

Peracids in water treatment: A critical review

Luukkonen

Pehkonen

2016

Critical Reviews in Environmental Science and Technology

256

122

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“…Significantly higher elevation in metallothioneins compared to that observed in the pristine area was apparent for dreissenids from three harbours (H1, H3, H4), while moderate rise in EROD activity (by 70-and 35%, respectively) was recorded in two harbours (H1, H4). Although EROD activity assessment in bivalves was considered a disputable method in outlining exposure to organic chemicals (Viarengo et al, 2007), we have included this endpoint based on evidences of significant induction of CYP-like enzymes and associated mixed function oxidase components in mussels either in in situ studies (de Lafontaine et al, 2000;Binelli et al, 2005;Okay et al, 2014) or laboratory experiments (Faria et al, 2009;Martin-Diaz et al, 2009;Sapone et al, 2016). Our results outlined just moderate spatial and temporal variability in the EROD activity of dreissenids inhabiting the investigated sites therefore, we considered for the moment these results as inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Interspecies comparison of selected pollution biomarkers in dreissenid spp. inhabiting pristine and moderately polluted sites

Farkas

Ács

Vehovszky

et al. 2017

Science of The Total Environment

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Stress biomarkers, which can outline impacts of contaminants in aquatic biota at the biochemical level, are increasingly used as early warning tools in environmental monitoring. Reliable biomarker based assessment schemes, however, request appropriate knowledge of baseline levels of selected endpoints, and the potential influence of a range of natural influencing factors (both abiotic and biotic) as well. In this study, we examined the interspecies variability of various biomarkers (metallothioneins (MT), ethoxyresorufin-Odeethylase activity (EROD), lipid peroxidation (LPO), DNA strand breaks (DNA_sb), vitellogenin-like proteins (Vtg)) in Dreissena polymorpha and Dreissena bugensis inhabiting either pristine-or moderately impacted sites of Lake Balaton (Hungary). Levels of all biomarkers considered revealed low interspecies variability in the two dreissenid species at all sampling sites, with consistently higher (but statistically insignificant) values in Dreissena polymorpha. Levels of all biomarkers varied within the two investigated seasons, with significant influence of the reproduction cycle particularly on the levels of metallothioneins and vitellogenin-like proteins. Each biomarker considered was elevated by October, with significantly higher values in the mussels inhabiting harbours. Insignificant spatial and temporal variability in the general health indicators (condition index, total protein content) of dreissenids was observed, which, in parallel with evident rise in biomarker levels, apparently suggest that the anthropogenic impacts in harbours affect mussel fitness yet at sub organismal level. Our data might serve useful basis for future environmental monitoring surveys, especially in habitats where the progressive replacement of Dreissena polymorpha by Dreissena bugensis is taking place, as the interspecies variability in susceptibility to chemical stress of the two species is well comparable.

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“…However, NaClO is very effective and low cost biocide used for water disinfection (Amin et al 2013), hypochlorite is a highly destructive, selective oxidant that reacts easily with all biomolecules. Moreover, dissolved chlorine dissociated into hypochlorite and hypochlorous ions, which penetrate cell membrane, may result in the formation of genotoxic, mutagenic, and/or carcinogenic disinfection byproducts (DPBs) (Sapone et al 2016) and are also associated with adverse reproductive outcomes (Nieuwenhuijsen et al 2000). As described by White and Broadley (2001), chlorine occurs in the soil predominantly as a Cl -anion, which does not form complexes readily, and is repelled from predominantly negatively charged mineral surfaces of many soil particles.…”

Section: Introductionmentioning

confidence: 99%

Plant stress activated by chlorine from disinfectants prepared on the base of sodium hypochlorite

Fargašová¹

2017

Nova Biotechnologica Et Chimica

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In this study, the phytotoxicity of disinfectants prepared on the base of sodium hypochlorite was determined. For our tests two commercial products, Savo and Dom Amor, as well as 10% NaClO solution were used. While Savo contained only NaClO, Dom Amor contained NaClO and earthworm enzymes. Products on the base of NaClO are used in households for cleaning and disinfection of floors, furniture, sanitary and kitchen equipment. Savo may be used for the disinfection of drinking waters as well. Products with NaClO are also used for bacteria, algae and pathogens reduction in irrigation waters. As a subject, young seedlings of mustard Sinapis alba L. were used for the study of chronic toxicity. The observed parameters of the inhibition of roots and shoots growth, dry (DM) and fresh (FM) mass as well as photosynthetic pigments production (chlorophyll a, b, carotenoids) and water content in the plants were determined. The results point out that Dom Amor was the most toxic for S. alba seedlings growth and the rank order of the FAC contents for both plant parts was arranged as: Dom Amor > Savo > NaClO. All disinfectants reduced the DM and FM of roots; however, they stimulated biomass production in the shoots. On the basis of the obtained results it could be concluded, that disinfectants stimulated photosynthetic pigments production and reduced water content mainly in the roots. Dom Amor did not significantly reduced the water content in the shoots and for this parameter the following rank orders of inhibition for roots and shoots could be arranged as NaClO > Dom Amor > Savo and NaClO > Savo > Dom Amor, respectively. All commercial products increased chlorophyll a (Chla) and the carotenoids (Car) content in the shoots. As significant increase was confirmed first for Chla whose content in the presence of NaClO at concentration 24 mL/L overextended that in the control by 3.5 times. The rank orders of stimulation for Chla and Car were NaClO > Savo > Dom Amor and Dom Amor > NaClO > Savo, respectively.

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Perturbation of xenobiotic metabolism in Dreissena polymorpha model exposed in situ to surface water (Lake Trasimene) purified with various disinfectants

Cited by 21 publications

References 59 publications

Peracids in water treatment: A critical review

Peracids in water treatment: A critical review

Interspecies comparison of selected pollution biomarkers in dreissenid spp. inhabiting pristine and moderately polluted sites

Plant stress activated by chlorine from disinfectants prepared on the base of sodium hypochlorite

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