Perspectives on Comparative Effectiveness Research

Nellesen, Dave; Birnbaum, Howard G.; Greenberg, Paul E.

doi:10.2165/11535790-000000000-00000

Cited by 12 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the USA for example, comparative effectiveness research focuses on the generation and synthesis of clinical evidence to compare the benefits and harms of alternative methods to address a clinical condition or improve the delivery of care. Its introduction and applicability to “real world” settings raises the question of the need for wider understanding of HE methods for those who may wish to articulate the cost impact of selected treatments on health systems, and for companies that are providing products associated with those treatments [7]. …”

Section: Introductionmentioning

confidence: 99%

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops

Craven

Allsop

Morgan

et al. 2012

Health Res Policy Sys

View full text Add to dashboard Cite

BackgroundWith increased governmental interest in value assessment of technologies and where medical device manufacturers are finding it increasingly necessary to become more familiar with economic evaluation methods, the study sought to explore the levels of health economics knowledge within small and medium-sized enterprises (SMEs) and to scope strategies they employ to demonstrate the value of their products to purchasers.MethodsA short questionnaire was completed by participants attending one of five workshops on product development in the medical device sector that took place in England between 2007 and 2011. From all responses obtained, a large proportion of participants were based in SMEs (N = 43), and these responses were used for the analysis. Statistical analysis using non-parametric tests was performed on questions with approximately interval scales. Qualitative data from participant responses were analysed to reveal emerging themes.ResultsThe questionnaire results revealed that 60% of SME participants (mostly company directors or managers, including product or project managers) rated themselves as having low or no knowledge of health economics prior to the workshops but the rest professed at least medium knowledge. Clinical trials and cost analyses or cost-effectiveness studies were the most highly cited means by which SMEs aim to demonstrate value of products to purchasers. Purchasers were perceived to place most importance on factors of safety, expert opinion, cost-effectiveness and price. However many companies did not utilise formal decision-making tools to prioritise these factors. There was no significant dependence of the use of decision-making tools in general with respect to professed knowledge of health economics methods. SMEs did not state a preference for any particular aspect of potential value when deciding whether to develop a product. A majority of SMEs stated they would use a health economics tool. Research and development teams or marketing and sales departments would most likely use one.ConclusionThis study points to the need for further research into the education requirements of SMEs in the area of Health Technology Assessment (HTA) and also for investigation into how SMEs engage with existing HTA processes as required by assessors such as NICE.

show abstract

Section: Introductionmentioning

confidence: 99%

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops

Craven

Allsop

Morgan

et al. 2012

Health Res Policy Sys

View full text Add to dashboard Cite

show abstract

“…[13][14][15][16] We need this type of research because there are gaps and variations in the quality of care delivered and clinical outcomes. We need to know the return on investment of healthcare dollars, and we need to know what works in "the real world."…”

Section: Methods For Acquiring Evidence: Comparative Effectivenessmentioning

confidence: 99%

Evidence and Education

Antman

2011

Circulation

View full text Add to dashboard Cite

“…For details, see www.pcori.org. Some think that public funding for CER may exceed $500 million per year by 2014 [29].…”

Section: Comparative Effectiveness Researchmentioning

confidence: 99%

Studying Group Behaviour: Cluster Randomized Clinical Trials

Kowalski¹

2013

AJCEM

View full text Add to dashboard Cite

Cluster randomized trials (CRTs) are experiments in which clusters of persons, rather than the persons themselves, are randomized to receive one of the interventions being studied. The use of CRTs has been increasing in response to the attention being paid to pragmatic as opposed to explanatory clinical trials, comparative effectiveness research, and community health promotional activities. We describe and illustrate the use of CRTs in these and other applications. Special attention is paid to ethical challenges in the design of such studies, and to tools for facilitating the implementation of interventions found to be efficacious in the trial into everyday clinical practice or effective community-wide programs. We argue that while CRTs have many useful and valid applications, there can be times when their use should be precluded due to ethical constraints. Special vigilance is required in research carried out in developing countries, where villages often seem to be a natural choice for clusters, but considerations of 'standard of care' may lead to control villages receiving no care or services. Full-fledged randomized controlled trials are not required to show that people who are doing poorly because of living in squalid conditions without proper sanitation and health care will, in the absence of change, continue to do so.

show abstract

Perspectives on Comparative Effectiveness Research

Cited by 12 publications

References 34 publications

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops

Engaging with economic evaluation methods: insights from small and medium enterprises in the UK medical devices industry after training workshops

Evidence and Education

Studying Group Behaviour: Cluster Randomized Clinical Trials

Contact Info

Product

Resources

About