2019
DOI: 10.1590/0103-8478cr20180595
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Abstract: Pain in the cancer patient is an important clinical manifestation that results in low life expectancy and poor prognosis. Pain may be related to tumor type, invasion of adjacent tissues, metastasis, and diagnostic and therapeutic procedures with variable response to analgesic therapy. Many studies have called attention due to their potential therapeutic effect in the modulation of pain and inflammation. Cannabinoid derivatives are chemical compounds obtained from Cannabis that act on specific receptors.Several… Show more

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Cited by 6 publications
(10 citation statements)
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References 25 publications
(48 reference statements)
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“…Em muitos países já foi aprovado o uso dos canabinoides para pacientes humanos (HERRERA; BURNEO, 2018). Os estudos sobre o uso da Cannabis sativa na Medicina Veterinária são incipientes, porém, a análise dos dados disponíveis sugere que a Cannabis também poderá oferecer diversos benefícios para os animais (REPETTI et al, 2019).…”
Section: Cannabis Sativaunclassified
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“…Em muitos países já foi aprovado o uso dos canabinoides para pacientes humanos (HERRERA; BURNEO, 2018). Os estudos sobre o uso da Cannabis sativa na Medicina Veterinária são incipientes, porém, a análise dos dados disponíveis sugere que a Cannabis também poderá oferecer diversos benefícios para os animais (REPETTI et al, 2019).…”
Section: Cannabis Sativaunclassified
“…O receptor CB1 localiza-se no SNC, no córtex frontal, cerebelo, núcleos da base, hipocampo e região límbica cerebral (BONFÁ; VINAGRE; FIGUEIREDO, 2008;BRUCKI et al, 2015;REPETTI et al, 2019), mas também estão presentes na medula espinhal, gânglios da medula dorsal, células endoteliais, adipócitos, tecido muscular, hepatócitos e trato gastrintestinal, sistema nervoso entérico e nervos periféricos (ABRAMS, 2016;BONFÁ;VINAGRE;FIGUEIREDO, 2008;REPETTI et al, 2019).…”
Section: Cannabis Sativaunclassified
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“…Cannabinoids exert their actions by binding with cannabinoid receptors (mainly CB 1 and CB 2 ) widely distributed in the peripheral and central nervous systems of human beings and other animals (Greb and Puschner, 2018). These receptors play important roles in many physiological processes such as pain, inflammation, immune function, and anxiety (Hartsel et al ., 2019; Repetti et al ., 2019). Moreover, the anticonvulsant effects of CBD appear to be due to the binding of specific transient receptor potential channels, which leads to decreased release of glutamate, activation of 5-hydroxytryptophan 1A receptors, and inhibition of adenosine reuptake (Carrier et al ., 2006; De Petrocellis et al ., 2011; Campos et al ., 2012; Sylantyev et al ., 2013).…”
Section: Introductionmentioning
confidence: 99%
“…Várias Pesquisas também focam o funcionamento dos receptores canabinóides tipo 1 (CB1) e o tipo 2 (CB2), e demonstraram que o uso da erva pode abrandar sintomas da esclerose múltipla, dor por inflamação ou neuropatias (REPETTI et al, 2019).…”
Section: Introductionunclassified