“…Therefore, micro-environmental factors do not appear to play an important role in the development of dry skin. The involvement of stress in atopic dermatitis (AD), a typical allergic dermatopathy in humans, has been recognized for many years [3,4,15,17]. Recently, detailed evaluation of the relationships between AD and the psychological state has also begun in Japan [9,10], and the interrelationship of psychological states such as depression, tension, and anxiety with the low water content of the stratum corneum in AD patients has been demonstrated.…”