Associations between changes in the psychosocial work environment and changes in personal work goals were investigated in a two-wave, two-year longitudinal study. Psychosocial work environment was studied within the context of the Effort-Reward Imbalance model (Siegrist, 1996) including the dimensions of effort, reward, and effort-reward imbalance. The participants consisted of 423 young Finnish managers (24-36 years at the baseline). The participants' most important personal work goals were categorized into seven content categories of competence, progression, well-being, job change, job security, organization, and finance at both measurement times. The ANCOVAs showed that there were differences especially in changes in the career opportunities factor of reward between participants whose goals changed during the study. First, participants who engaged in job change goals reported a decrease in reward, whereas participants who engaged in competence or organizational goals reported an increase in reward. Second, participants who disengaged from job change goals reported an increase in reward and a reduction in effort-reward imbalance. Finally, participants who disengaged from job security goals reported a reduction in reward and an increase in effort-reward imbalance. The study highlighted the central role of career opportunities in goal pursuit, which can also bear implications on the occupational well-being of employees.