The use of UAVs in areas ranging from agriculture over urban services to entertainment or simply as a hobby has rapidly grown over the last years. Regarding serious/commercial applications, UAVs have been considered in the literature, especially as mobile sensing/actuation platforms (i.e., as a delivery platform for an increasingly wide range of sensors and actuators). With regard to timely, cost-effective and very rich data acquisition, both, NEC Research as well as TNO are pursuing investigations into the use of UAVs and swarms of UAVs for scenarios where high-resolution requirements, prohibiting environments or tight time constraints render traditional approaches ineffective. In this review article, we provide a brief overview of safety and security-focused application areas that we identified as main targets for industrial and commercial projects, especially in the context of intelligent autonomous systems and autonomous/semi-autonomously operating swarms. We discuss a number of challenges related to the deployment of UAVs in general and to their deployment within the identified application areas in particular. As such, this article is meant to serve as a review and overview of the literature and the state-of-the-art, but also to offer an outlook over our possible (near-term) future work and the challenges that we will face there.