Persistent luminescence-polypyrrole nanocomposite for dual-modal imaging and photothermal therapy of mammary cancer

Wu, Shuqi; Li, Yang; Zhang, Ruofei; Ding, Wei-Hang; Xu, Letong; Zhang, Lianbing

doi:10.1016/j.talanta.2020.121435

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…reported that polypyrrole modification can reduce the luminescent intensity of Cr 3+ ‐doped zinc gallogermanates. [ 87 ] These discoveries demonstrate that the influence of surface modification on the luminescent intensity of PLMs should be taken into account. On the other hand, it is necessary to make the synthetic process of PLMs green and low consumed and many recently developed synthetic methods such as microbial synthesis or biosynthesis is helpful to achieve the goal.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is still a long way to achieve the goal of “top‐down” synthesis, denoting the design and synthesis of materials under the guidance of a clear mechanism. Furthermore, an energy transfer process might happen from PLMs to modifiers and thus reduce or quench the luminescence, [ 87‐88 ] which could lower the sensitivity of biosensing and bioimaging. For example, Zhang et al .…”

Section: Discussionmentioning

confidence: 99%

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Surface Modified Persistent Luminescence Probes for Biosensing and Bioimaging: A Review

et al. 2021

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Persistent luminescence materials (PLMs) are a class of unique luminescent materials that can remain luminescent for a few milliseconds to days without constant excitation. By virtue of the super long decay time, PLMs have been extensively explored in biosensing and bioimaging applications to elimin ate autofluorescence interference and improve signal-to-noise ratio in complex samples and tissues. However, nude PLMs often suffer from the poor stability, selectivity, and biocompatibility in biological system and in vivo, which greatly impedes their applications in biomedicine and bioanalysis. Remarkably, surface modification is a viable solution that endows PLMs with span-new features and can make PLMs suitable for organisms by altering PLMs' interaction with biological system. In this review, commonly used strategies for surface modification of PLMs are briefly introduced, and the applications of surface modified PLMs in biosensing and bioimaging as well as their challenges are summarized. Qiang Luo (top left) received his B.S. degree in chemistry from Lanzhou University in 2018. He is currently a master student under the supervision of Prof. Quan Yuan at Hunan University. His research interests include the development of functional nanomaterials for biosensing and bioimaging. Wenjie Wang (top right) received his B.S. degree from North China Electric Power University in 2018. He is currently a master student under the supervision of Prof. Quan Yuan at Hunan University. His research interests include the synthesis of inorganic nanomaterials for biological application. Jie Tan (bottom left) earned her Ph.D. degree from Zhejiang University in 2016. Then she joined the team of Prof. Weihong Tan in Hunan University as a postdoctoral fellow. Currently, she is an associate professor at Hunan University. Her main research interest is the design of chemically modified nucleic acids for biosensing. Quan Yuan (bottom right) received her B.S. degree from Wuhan University and Ph.D. degree from Peking University. Afterwards, she worked as a postdoctoral researcher in the group of Prof. Weihong Tan at University of Florida. Currently, she is a professor in Hunan University. Her research interests are the construction of nucleic acid nanomaterials and related biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surface Modified Persistent Luminescence Probes for Biosensing and Bioimaging: A Review

et al. 2021

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“…Zhang et al also reported polypyrrole-coated PLNPs which enabled good PersL/PA imaging and efficient photothermal effect on tumor inhibition (Fig. 11) [98].…”

Section: Plnps Based Photothermal Therapymentioning

confidence: 96%

“…The first strategy focuses on the use of surface chemical modifications to attach another imaging modality. For [98]. Wang et al also presented GdAlO 3 :Mn 4+ ,Ge 4+ @Au (GAMG@Au) core-shell nanoprobes with MR/CT/PersL third-modals imaging properties [99].…”

Section: In Vivo Multimodal Imagingmentioning

confidence: 99%

Persistent luminescence nanoparticles for cancer theranostics application

et al. 2021

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Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLNPs are also widely used in persistent luminescence (PersL) imaging-guided tumor therapy. In this review, we first summarize the recent developments in the synthesis and surface functionalization of PLNPs, as well as their toxicity studies. We then discuss the in vivo PersL imaging and multimodal imaging from different excitation sources. Furthermore, we highlight PLNPs-based cancer theranostics applications, such as fluorescence-guided surgery, photothermal therapy, photodynamic therapy, drug/gene delivery and combined therapy. Finally, future prospects and challenges of PLNPs in the research of translational medicine are also discussed.

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“…Persistent luminescence (PeL) is a phenomenon where light is emitted for long periods, from minutes to hours, after the excitation, resulting in a glow-in-the-dark phenomenon [42][43][44][45][46][47][48][49][50][51][52][53][54]. If we come back to the analogy in Figure 1, now imagine that we use a material capable of luminescing without a continuous excitation.…”

Section: Introductionmentioning

confidence: 99%

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

et al. 2020

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The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.

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Persistent luminescence-polypyrrole nanocomposite for dual-modal imaging and photothermal therapy of mammary cancer

Cited by 19 publications

References 34 publications

Surface Modified Persistent Luminescence Probes for Biosensing and Bioimaging: A Review

Surface Modified Persistent Luminescence Probes for Biosensing and Bioimaging: A Review

Persistent luminescence nanoparticles for cancer theranostics application

Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

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