volume 6, issue 1, Pe1000731 2010
DOI: 10.1371/journal.ppat.1000731
View full text
|
Sign up to set email alerts
|
Share

Abstract: Trypanosomes are parasites that cycle between the insect host (procyclic form) and mammalian host (bloodstream form). These parasites lack conventional transcription regulation, including factors that induce the unfolded protein response (UPR). However, they possess a stress response mechanism, the spliced leader RNA silencing (SLS) pathway. SLS elicits shut-off of spliced leader RNA (SL RNA) transcription by perturbing the binding of the transcription factor tSNAP42 to its cognate promoter, thus eliminating t…

Expand abstract