Persistent deficiency of circulating mucosal-associated invariant T (MAIT) cells in ANCA-associated vasculitis

Braudeau, Cécile; Amouriaux, Karine; Néel, A.; Herbreteau, Guillaume; Salabert, Nina; Rimbert, Marie; Martin, Jérôme C.; Hémont, Caroline; Hamidou, M.; Josien, Régis

doi:10.1016/j.jaut.2016.03.015

Cited by 52 publications

(56 citation statements)

References 33 publications

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“…Similar data have been shown in other autoimmune diseases and chronic viral infections, and decreased levels of MAIT cells were reported in ANCA‐positive vasculitis, ankylosing spondylitis, Sjogren' syndrome, ulcerative colitis and SLE . In ulcerative colitis and rheumatoid arthritis, a decrease in blood circulating MAIT cells was associated with their enrichment in synovitis and inflamed mucosa, arguing for the implication of MAIT cells as pro‐inflammatory trigger on local sites.…”

Section: Discussionsupporting

confidence: 83%

“…Another report on ulcerative colitis showed decreased blood and mucosal levels of MAIT cells, with enhanced pro‐apoptotic features. The decrease in MAIT cells with age has been previously reported in healthy controls and other autoimmune diseases . Although we have not studied the MAIT cell activation phenotype and the capacity to secrete inflammatory cytokines, we can speculate that activated MAIT profile and redistribution to peripheral sites such as the digestive tract, skin and lung could constitute an additional mechanism of persistent pro‐inflammatory profile in progressive SSc disease.…”

Section: Discussionmentioning

confidence: 77%

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Mucosal‐associated Invariant Cells are Deficient in Systemic Sclerosis

et al. 2017

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Systemic sclerosis (SSc) is an autoimmune disease, characterized by fibrosis of the skin and other organs, vascular impairment and deficient immune responses. Mucosal-associated invariant T cells (MAIT) have been involved in various inflammatory and autoimmune diseases. The aims of this study were to determine the frequencies of MAIT cells in the blood of patients with systemic sclerosis (SSc) and to compare their distribution in different types of SSc. Blood samples from patients with SSc and healthy controls were examined by flow cytometer to analyse the frequencies of MAIT and γδ T cells. We demonstrate that in SSc the frequencies and absolute numbers of MAIT and γδ T cells are significantly reduced in comparison with healthy controls. MAIT and γδ T cells did not correlate with C-reactive protein, BNP, pulmonary involvement or median skin fibrosis scale, steroid amount or disease duration. In addition, MAIT and γδ T cells decrease did not stratify with gender, interstitial lung disease or active digital ulcers. Functional studies are necessary to determine the signification of MAIT cells decrease in systemic sclerosis.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 77%

Mucosal‐associated Invariant Cells are Deficient in Systemic Sclerosis

et al. 2017

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“…Most importantly, the reduced numbers of IL‐9‐producing ILC2s that were found in the blood and synovia of rheumathoid arthritis patients with active disease increased with disease remission, suggesting that ILC2s have an anti‐inflammatory function in human autoimmune diseases . In support of this hypothesis, ILC2s numbers were found to be reduced in the peripheral blood of patients with anti‐neutrophil cytoplasmatic antibody‐associated vasculitis, another important human autoimmune disease . Furthermore, it has been shown that human ILC2s are sensible to interferon‐mediated inhibition in vitro .…”

Section: Discussionmentioning

confidence: 86%

T cell‐derived IFN‐γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus

et al. 2018

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Innate lymphoid cells (ILCs) are important regulators of the immune response and play a crucial role in the restoration of tissue homeostasis after injury. GATA-3 IL-13- and IL-5-producing group 2 innate lymphoid cells (ILC2s) have been shown to promote tissue repair in barrier organs, but despite extensive research on ILCs in the recent years, their potential role in autoimmune diseases is still incompletely understood. In the present study, we investigate the role of ILC2s in the MRL/MpJ-Fas (MRL-lpr) mouse model for severe organ manifestation of systemic lupus erythematosus (SLE). We show that in these MRL-lpr mice, progression of lupus nephritis is accompanied with a reduction of ILC2 abundance in the inflamed renal tissue. Proliferation/survival and cytokine production of kidney-residing ILC2s was suppressed by IFN-γ and, to a lesser extent, by IL-27 which were produced by activated T cells and myeloid cells in the nephritic kidney, respectively. Most importantly, restoration of ILC2 numbers by IL-33-mediated expansion ameliorated lupus nephritis and prevented mortality in MRL-lpr mice. In summary, we show here that development of SLE-like kidney inflammation leads to a downregulation of the renal ILC2 response and identify an ILC2-expanding therapy as a promising treatment approach for autoimmune diseases.

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“…26 Serum IL-25 concentration in patients with active EGPA is higher than in those with inactive EGPA or in healthy subjects and is correlated with disease activity and peripheral blood eosinophil count. 30 The frequencies of mucosal-associated invariant T cells and ILC2s are lower in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis with microscopic polyangiitis, granulomatosis with polyangiitis, and EGPA, both in active disease and remission, compared with in healthy subjects. 8,28 MAIT cells have immune regulatory functions at mucosal sites and produce the pro-inflammatory cytokines IFN-γ, TNF-α, and IL-17, which have cytotoxic activity.…”

Section: Introductionmentioning

confidence: 92%

“…25 Serum soluble ST2 and IL-33 concentrations in patients with microscopic polyangiitis or granulomatosis with polyangiitis (formerly Wegener's granulomatosis) are higher than in healthy subjects, and soluble ST2 concentration, but not IL-33 concentration, is associated with disease activity. 30 The numbers of ILC2s and ILC3s are decreased, and the numbers of ILC1s are increased in patients with both granulomatosis with polyangiitis and microscopic polyangiitis in the acute phase compared with in healthy subjects; total ILC count is correlated with Birmingham Vasculitis Activity Score. 27 Mucosa-associated invariant T (MAIT) cells and ILCs with innate functions have been described at mucosal sites.…”

Section: Introductionmentioning

confidence: 94%