Persistency of high proinflammatory cytokine levels from colostrum to mature milk in preeclampsia

Erbağcı, Ahmet; Çekmen, Mustafa; Balat, Özcan; Balat, Ayşe; Aksoy, Fuat; Tarakçıoğlu, Mehmet

doi:10.1016/j.clinbiochem.2005.05.004

Cited by 37 publications

(38 citation statements)

References 33 publications

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“…These results confirm those found in studies with human milk from different stages of lactation, with IL-6 being relatively lower in mature milk compared to colostrum (Meki et al 2003;Erbagci et al 2005).…”

Section: Discussionsupporting

confidence: 94%

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Temporal fluctuations of cytokine concentrations in human milk

Morais

Honório-França

Silva

et al. 2015

Biological Rhythm Research

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Section: Discussionsupporting

confidence: 94%

“…This cytokine profile in colostrum may reflect inflammatory changes associated with pregnancy and childbirth (Erbagci et al 2005), and IL-6, TNF-α and IL-17 may have pro-inflammatory activities (Meki et al 2003;Saito et al 2010;Zhang & An 2007).…”

Section: Discussionmentioning

confidence: 99%

Temporal fluctuations of cytokine concentrations in human milk

Morais

Honório-França

Silva

et al. 2015

Biological Rhythm Research

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“…An increase of cytokines in breast milk has been reported from different stages of maternal lactation: on the one hand, maternal diseases during pregnancy—like pre-eclampsia or allergies—can lead to a rise in cytokines of breast milk [39]. In addition, the systematic review of the literature performed here showed a modulation of cytokine levels in breast milk during inflammatory chest diseases during lactation.…”

Section: Discussionmentioning

confidence: 75%

Inflammatory Breast Diseases during Lactation: Health Effects on the Newborn—A Literature Review

Wöckel

Abou-Dakn

Beggel

et al. 2008

Mediators of Inflammation

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Breastfeeding-associated inflammatory breast diseases appear especially during the first twelve weeks postpartum and are the most common reason for early cessation of breastfeeding. It also becomes increasingly evident that these inflammatory mammary diseases are triggered or perpetuated in a large part by psychosocial stress. Immunological processes taking place during this cascade in the mammary gland and consequences for the breastfeed newborn are mostly yet unknown. This review summarizes insights from studies on modulation of cytokine levels in breast milk during inflammatory processes like milk stasis and mastitis systematically. It also gives an overview on possible pathological effects, which these cytokine changes in the breast milk might have on the newborn.

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“…4,30,31 It seems likely that the same set of glycosyltransferases is involved in elongation and branching of glycans of glycoconjugates and HMOs in lactating mammary glands. 3,4,33 Additionally, hormones, especially at the hormone target organs, such as the mammary gland, can affect the local synthesis 34 and glycosylation of glycoproteins. Lactation, being a unique neuroendocrine state, is associated with an increase in prolactin 35 and a decrease in estrogen secretion, 3 which are known to regulate expression of different glycosyltransferases involved in O-and N-linked glycan synthesis.…”

Section: Discussionmentioning

confidence: 99%

Lactation Stage-Related Expression of Sialylated and Fucosylated Glycotopes of Human Milk α-1-Acid Glycoprotein

Orczyk-Pawiłowicz

Hirnle

Berghausen-Mazur

et al. 2014

Breastfeeding Medicine

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Background: Because terminal sugars of a-1-acid glycoprotein (AGP) are reported to be involved in antiinflammatory and immunomodulatory processes, their expressions might have an influence on the proper function of immune system of newborns. Here, relative amounts of sialylated and fucosylated glycotopes on human milk AGP over normal lactation were investigated. Materials and Methods: AGP concentration and relative amounts of its sialylated and fucosylated glycovariants were analyzed in early colostrum, colostrum, and transitional and mature milk samples of 127 healthy mothers by lectin-AGP enzyme-linked immunosorbent assay using a2,3-and a2,6-sialic acid and a1,2-, a1,3-, and a1,6-fucose specific biotinylated Maackia amurensis, Sambucus nigra, Ulex europaeus, Tetragonolobus purpureus, and Lens culinaris lectins, respectively. Results: AGP concentration in human milk was about 30 times lower than in plasma of lactating mothers and decreased gradually over lactation. Milk AGP showed significantly higher expression of sialylated and fucosylated glycotopes in comparison with those of plasma AGP. Milk AGP glycovariants containing a2,6-sialylated and a1,6-and a1,2-fucosylated glycotopes showed the highest relative amounts in early colostrums. With progression of lactation, the expressions of glycotopes a1,2-fucosylated decreased starting from Day 4 and those of a2,6-sialylated and a1,6-fucosylated from Day 8 of lactation, whereas the level of a2,3-sialyl-glycotope was almost constant over 45 days of lactation. In contrast, the expression of a1,3-linked fucose on AGP was low in colostrums and significantly higher in transitional and mature milk. Conclusions: The relative amounts of sialylated and fucosylated glycovariants of human hindmilk AGP significantly varied between Days 2 and 45 of normal lactation.

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Persistency of high proinflammatory cytokine levels from colostrum to mature milk in preeclampsia

Cited by 37 publications

References 33 publications

Temporal fluctuations of cytokine concentrations in human milk

Temporal fluctuations of cytokine concentrations in human milk

Inflammatory Breast Diseases during Lactation: Health Effects on the Newborn—A Literature Review

Lactation Stage-Related Expression of Sialylated and Fucosylated Glycotopes of Human Milk α-1-Acid Glycoprotein

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