Persistence of T-cell clones in psoriatic lesions

Chang, J. C.

doi:10.1001/archderm.133.6.703

Cited by 22 publications

(17 citation statements)

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“…Putative pathogenic clones had significantly increased usage of TCR Vβ2, Vβ6, and Vβ13. These results are in agreement with 2 prior studies demonstrating preferential use of Vβ13 by T cells in psoriatic lesions and by a melanocyte antigen-specific autoreactive T cell clone from a patient with psoriasis (7,8).…”

Section: Oligoclonal Populations Of T Cells Are Present In Clinicallysupporting

confidence: 93%

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones

Matos

O’Malley

Lowry

et al. 2017

Journal of Clinical Investigation

226

197

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Kit (QIAGEN) per the manufacturer's instructions, with overnight tissue digestion. This method generated 155-3730 ng DNA per sample.HTS analyses: immunosequencing. For each sample, DNA was extracted from skin biopsies, then TCRβ CDR3, TCRγ CDR3, TCRα CDR3, and TCRδ CDR3 regions were amplified and sequenced using immunoSEQ (Adaptive Biotechnologies). Bias-controlled V and J gene matitis, allergic contact dermatitis, and pityriasis lichenoides were obtained with IRB approval from the Pathology Specimen Locator Core at Brigham and Women's Hospital.DNA isolation from skin. DNA was isolated from frozen, OCTembedded skin samples. 30 Cryosections of 10-μm thickness were cut, and DNA extraction was carried out using the QIAamp DNA Mini

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Section: Oligoclonal Populations Of T Cells Are Present In Clinicallysupporting

confidence: 93%

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones

Matos

O’Malley

Lowry

et al. 2017

Journal of Clinical Investigation

226

197

View full text Add to dashboard Cite

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“…This Ag-specific T cell response is stable and dominant. The same T cell clones were identified in repeated biopsies taken over periods Ͼ3 years from different skin lesions, while they were absent from nonaffected skin or blood of the same patient (22,23,30,31). The obvious continuity and selectivity of the psoriatic T cell response may be used to decipher the psoriatic immune cascade by tracking the pathogenic T cell clones.…”

Section: Discussionmentioning

confidence: 87%

“…Several recent studies have demonstrated that psoriatic inflammation is promoted by a highly conserved clonal T cell response (22,23,30,31). We therefore sought to examine the suspected relationship between streptococcal angina and psoriatic inflammation on the level of T cells.…”

Section: Psoriatic Skin Lesion But Not Blood or Tonsils Show A Highlymentioning

confidence: 99%

Identical TCR β-Chain Rearrangements in Streptococcal Angina and Skin Lesions of Patients with Psoriasis Vulgaris

Diluvio

Vollmer

Besgen

et al. 2006

The Journal of Immunology

130

101

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Tonsillar infection with Streptococcus pyogenes may induce several nonsuppurative autoimmune sequelae. The precise pathogenetic mechanisms behind this clinically well-established association are still unresolved. Using TCR analysis, we sought to identify a link between streptococcal tonsillitis and the T cell-mediated autoimmune response in psoriasis. Three patients with streptococcal-induced psoriasis underwent tonsillectomy. Using size spectratyping and sequencing of TCR β-chain variable region gene (TCRBV) rearrangements, we compared the TCR usage of psoriatic skin lesions, blood, tonsils, and tonsillar T cells fractionated according to the expression of the skin addressin “cutaneous lymphocyte-associated Ag” (CLA). TCRBV-size spectratype analysis of the blood lymphocytes, tonsils, and the CLA-negative tonsillar T cells revealed largely unselected T cell populations. Instead, TCRBV gene families of the psoriatic lesions and skin-homing CLA-positive tonsillar T cells displayed highly restricted spectratypes. Sequencing of TCRBV cDNA identified various clonal TCRBV rearrangements within the psoriatic lesions that indicated Ag-driven T cell expansion. Several of these clonotypes were also detected within the tonsils and, in one of the patients, within the small subset of CLA-positive tonsillar T cells, suggesting that T cells from the same T cell clones were simultaneously present within skin and tonsillar tissue. Because after tonsillectomy psoriasis cleared in all three patients our observations indicate that T cells may connect psoriatic inflammation to streptococcal angina. They suggest that the chronic streptococcal immune stimulus within the tonsils could act as a source for pathogenic T cells in poststreptococcal disorders, and they may help to explain why eliminating this source with tonsillectomy may improve streptococcal-induced sequelae.

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“…Снижение экспрессии рецепторов к IL 2 прерывает патогенетическую цепь цито кинных взаимодействий при псориазе, приводя щих к нарушению процессов пролиферации и дифференцировки клеток эпидермиса. Известно, что пролиферация лимфоцитов у больных псори азом в местах поражения усилена [5]. Снижение пролиферативной активности лимфоцитов в оча гах поражения больных псориазом при примене нии кларитромицина также может оказать благо приятное влияние на состояние кожного процес са.…”

Section: Discussionunclassified

The Grounds of Claritromycin Use in the Treatment of Psoriasis

Рыбкина¹

2014

Med. immunol.

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Медицинская Иммунология 2005, Т. 7, № 4, стр 405 410 © 2005, СПб РО РААКИ 405 Рыбкина В.Л. Оригинальные статьи Научно исследовательский кожно венерологический институт МЗ Республики Казахстан ОБОСНОВАНИЕ ПРИМЕНЕНИЯ КЛАРИТРОМИЦИНА ДЛЯ ЛЕЧЕНИЯ ПСОРИАЗАРезюме. Изучено влияние кларитромицина на процессы пролиферации и дифференцировки кератино цитов, экспрессию кластеров дифференцировки и пролиферативную активность лимфоцитов больных псо риазом in vitro. Установлено, что в культуре кларитромицин в дозе 2 мкг/мл угнетал пролиферацию керати ноцитов больных псориазом и увеличивал степень их дифференцировки. Влияние этого препарата было опосредованным, оно осуществлялось через CD4 + лимфоциты. Кроме того, кларитромицин in vitro умень шал количество СD25 + лимфоцитов и снижал спонтанную и ФГА индуцированную пролиферацию лим фоцитов больных псориазом. Полученные данные создают предпосылки для включения этого препарата в схему лечения псориаза. Озерск, пр. Карла Маркса 23, кв. 106. Тел: (35171) 7 71 71 (дом), 7 46 08 (раб).

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Persistence of T-cell clones in psoriatic lesions

Cited by 22 publications

References 0 publications

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones

Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones

Identical TCR β-Chain Rearrangements in Streptococcal Angina and Skin Lesions of Patients with Psoriasis Vulgaris

The Grounds of Claritromycin Use in the Treatment of Psoriasis

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