Persistence and fate of fenthion in olives and olive products

Cabras, Paolo; Garau, Valentino; Melis, Maria Rosaria; Pirisi, Filippo M.; Spanedda, Lorenzo

doi:10.1021/jf00036a041

Cited by 28 publications

(27 citation statements)

References 1 publication

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“…It is known that fenthion is accumulated in the environment (Fukushima 1991;Lacorte et al 1997;Pereira and Hostettler 1993). Fenthion and its metabolites were detected in rice and olive oil at concentrations of about 10 and 1 ppm, respectively (Cabras et al 1993;Fukuda et al 1962). These compounds were also detected in river water near Osaka, Japan at 20-70 ng/L (Yamaguchi and Fukushima 1994).…”

Section: Discussionmentioning

confidence: 99%

Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds.

Kawa

Suzuki

Ohta

et al. 2003

Environ Health Perspect

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We investigated the endocrine-disrupting actions of the organophosphorus pesticide fenthion and related compounds and the influence of metabolic transformation on the activities of these compounds. Fenthion acted as an antagonist of the androgenic activity of dihydrotestosterone (10(-7)M) in the concentration range of 10(-6)-10(-4)M in an androgen-responsive element-luciferase reporter-responsive assay using NIH3T3 cells. The antiandrogenic activity of fenthion was similar in magnitude to that of flutamide. Fenthion also tested positive in the Hershberger assay using castrated male rats. Marked estrogenic and antiestrogenic activities of fenthion and related compounds were not observed in MCF-7 cells. When fenthion was incubated with rat liver microsomes in the presence of NADPH, the antiandrogenic activity markedly decreased, and fenthion sulfoxide was detected as a major metabolite. The oxidase activity toward fenthion was exhibited by cytochrome P450 and flavin-containing monooxygenase. Fenthion sulfoxide was negative in the screening test for antiandrogens, as was fenthion sulfone. However, when fenthion sulfoxide was incubated with liver cytosol in the presence of 2-hydroxypyrimidine, an electron donor of aldehyde oxidase, the extract of the incubation mixture exhibited antiandrogenic activity. In this case, fenthion was detected as a major metabolite of the sulfoxide. Metabolic interconversion between fenthion and fenthion sulfoxide in the body seems to maintain the antiandrogenic activity.

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Section: Discussionmentioning

confidence: 99%

Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds.

Kawa

Suzuki

Ohta

et al. 2003

Environ Health Perspect

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“…These OPPs are expected to exist in both gas and particle phases in the atmosphere on the basis of their vapor pressures ranging from 10 À3 to 10 À4 Pa at room temperature. Great efforts have been made into the studies on the three OPPs, but most of which focused on the treatment technologies, toxic effects, and the metabolites in plants, waters and soils (Cabras et al, 1993;Minelli et al, 1996;Kaur et al, 1997;Bavcon et al, 2003;Pico et al, 2007;Wu and Linden, 2008;Slotkin et al, 2009;Fan et al, 0045-6535/$ -see front matter Ó 2011 Elsevier Ltd. All rights reserved. doi:10.1016/j.chemosphere.2011.12.031 2011).…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous reactions of suspended parathion, malathion, and fenthion particles with NO3 radicals

Liu¹,

Yang²,

Gan³

et al. 2012

Chemosphere

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“…Residual pesticides are known to be decomposed by various natural conditions in the environment: by hydrolysis in water, 1,2) photodegradation, [3][4][5][6][7] metabolism in plants 8,9) and animals, 10,11) and bacteriological degradation in soil. 12,13) The degraded products of the pesticides then have the potential to be ingested by humans with agricultural products.…”

Section: Introductionmentioning

confidence: 99%

Comparative Photodegradation Study of Fenthion and Disulfoton under Irradiation of Different Light Sources in Liquid- and Solid-Phases

Hirahara

Ueno

Nakamuro

2001

JOURNAL OF HEALTH SCIENCE

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To assess the photodegradation extent of the organophosphorus pesticides, fenthion and disulfoton in the environment, degradation rates of their chemicals under irradiation by visible light and each region of the ultraviolet (UV) sources, UVA (320-400 nm radiation), UVB (280-320 nm radiation) and UVC (250-260 nm radiation) in liquid-and solid-phases were determined and their photolysis products identified. Although visible light did not cause photodegradation of either fenthion or disulfoton even after the maximal irradiation of 8 hr in both phases, all the ranges of UV sources resulted in the photolysis of both pesticides, despite the solid-phase. The photolysis rates of fenthion under UVB and UVC irradiation in both phases were higher than that under UVA irradiation and also exceeded all of the degradation rates of disulfoton. This confirms that fenthion is more readily degraded than disulfoton in the UVB range. Fenthion sulfoxide and disulfoton sulfoxide were identified as oxidative photolysis products whose photolysis rates were considerably slower than parent compounds, and the oxidation reaction of both pesticides in the liquid-phase was superior to those on the solid-phase, indicating that dissolved oxygen in water is an important factor affecting the photolysis. These results suggest that fenthion in the environment is more rapidly degraded by UVB irradiation in natural sunlight than disulfoton, and sulfoxides of both pesticides remain stable as a photolysis product in the environment.

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Persistence and fate of fenthion in olives and olive products

Cited by 28 publications

References 1 publication

Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds.

Antiandrogenic activity and metabolism of the organophosphorus pesticide fenthion and related compounds.

Heterogeneous reactions of suspended parathion, malathion, and fenthion particles with NO3 radicals

Comparative Photodegradation Study of Fenthion and Disulfoton under Irradiation of Different Light Sources in Liquid- and Solid-Phases

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