J. Neurosci. Res. volume 85, issue 10, P2216-2223 2007 DOI: 10.1002/jnr.21360 View full text
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Indrapal N. Singh, Patrick G. Sullivan, Edward D. Hall

Abstract: Peroxynitrite-mediated oxidative damage has been implicated in brain mitochondrial respiratory dysfunction after traumatic brain injury (TBI), which precedes the onset of neuronal loss. The aim of this study was to investigate the detrimental effects of the peroxynitrite donor SIN-1 (3-morpholinosydnonimine) on isolated brain mitochondria and to screen penicillamine, a stoichiometric (1:1) peroxynitrite-scavenging agent, and tempol, a catalytic scavenger of peroxynitrite-derived radicals, as antioxidant mitoch…

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