Peroxisome proliferator-activated receptor-γ–coactivator 1α (PGC-1α) gene expression in chronic kidney disease patients on hemodialysis: relation to hemodialysis-related cardiovascular morbidity and mortality

Tayae, Eman; Nassra, Rasha A.; Naga, Yasmine

doi:10.1007/s11255-017-1628-5

Cited by 6 publications

(7 citation statements)

References 46 publications

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“…CKD is also a case of oxidative stress and inflammation. Oxidative stress may be considered as a means for predicting morbidity and mortality in CKD patients . CKD patients have low levels of antioxidants and high concentrations of pro‐oxidants .…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress may be considered as a means for predicting morbidity and mortality in CKD patients. 10,11 CKD patients have low levels of antioxidants and high concentrations of pro-oxidants. 12,13 Meanwhile, oxidative stress and inflammation are interwoven; it is not only oxidative stress that acts as a trigger for inflammatory response, but also inflammation in turn recruits phagocytes into an injured region, leading to production of oxygen radicals.…”

Section: Introductionmentioning

confidence: 99%

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Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

et al. 2019

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BACKGROUND Pomegranate has antioxidant, cardioprotective and anti‐inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty‐one hemodialysis patients were randomly assigned to one of two groups: PJ‐treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4‐week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention‐to‐treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high‐density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low‐density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin‐6 decreased in PJ (P < 0.001) and increased in the control group (P ≤ 0.001). The changes of these biomarkers were significantly different between the two conditions. CONCLUSIONS Eight‐week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high‐density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. © 2019 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

et al. 2019

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“…Considerable evidence has indicated that hemodialysis patients are often accompanied by lipid metabolism disorders, cardiovascular complications in patients with one of the important factors [1-5]. However, the etiology and underlying mechanism are not entirely clear.…”

Section: Introductionmentioning

confidence: 99%

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Wang¹,

Wang

et al. 2017

J Clin Med Res

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BackgroundThe aim was to investigate the clinical characteristics of lipid metabolism and the effect of apolipoprotein E (ApoE) gene polymorphism on lipid metabolism in hemodialysis patients.MethodsThe serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), ApoA1, ApoB, ApoE and lipoprotein Lp(a) were detected by polymerase chain reaction-restriction fragment length (PCR-RFLP).ResultsThe level of serum TG was significantly increased and the level of HDLC was significantly decreased in hemodialysis patients. Serum TG level was 33% higher than normal, and HDLC was 10.4% less than normal. The correlation analysis showed that TG level was significantly correlated with serum albumin level and extracorporeal circulation blood flow during dialysis. HDLC was significantly correlated with KT/V. The incidence of hypertension in hemodialysis patients was 73.6% and cardiovascular disease was 25%. The level of TG in the cardiovascular disease group was significantly higher than that in the non-cardiovascular disease group, and there was no significant difference between the hypertensive group and the non-hypertensive group. ApoE gene polymorphism test showed that the frequency of ApoE genotype ε3/3 and allele ε3 was the highest in hemodialysis patients, and the levels of TC, TG and LDLC were higher in ApoE genotype ε3/4 + ε4/4.ConclusionThe levels of serum TG and ApoB were significantly increased in patients with hemodialysis, and HDLC and other indexes were significantly decreased. The level of TG in patients with cardiovascular complications was significantly higher than in patients without complications. TG level was significantly correlated with serum albumin level and extracorporeal circulation blood flow during dialysis. HDLC was significantly correlated with KT/V. Hemodialysis patients who had ApoE allele ε4 are prone to lipid metabolism disorders.

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“…Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1 (PGC-1α), the energetic regulator, is acknowledged as a critical signaling pathway regulating COX6c expression [ 25 ]. As a powerful regulator of cellular energy metabolism, PGC-1α is primarily expressed in tissues and organs rich in mitochondria, such as the heart, liver, kidney, brain, brown adipose tissue, and skeletal muscle.…”

Section: Regulation Of Cox6cmentioning

confidence: 99%

Novel role of COX6c in the regulation of oxidative phosphorylation and diseases

Wang

Xue

et al. 2022

Cell Death Discov.

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Cytochrome c oxidase subunit VIc (COX6c) is one of the most important subunits of the terminal enzyme of the respiratory chain in mitochondria. Numerous studies have demonstrated that COX6c plays a critical role in the regulation of oxidative phosphorylation (OXPHOS) and energy production. The release of COX6c from the mitochondria may be a hallmark of the intrinsic apoptosis pathway. Moreover, The changes in COX6c expression are widespread in a variety of diseases and can be chosen as a potential biomarker for diagnosis and treatment. In light of its exclusive effects, we present the elaborate roles that COX6c plays in various diseases. In this review, we first introduced basic knowledge regarding COX6c and its functions in the OXPHOS and apoptosis pathways. Subsequently, we described the regulation of COX6c expression and activity in both positive and negative ways. Furthermore, we summarized the elaborate roles that COX6c plays in various diseases, including cardiovascular disease, kidney disease, brain injury, skeletal muscle injury, and tumors. This review highlights recent advances and provides a comprehensive summary of COX6c in the regulation of OXPHOS in multiple diseases and may be helpful for drug design and the prediction, diagnosis, treatment, and prognosis of diseases.

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Peroxisome proliferator-activated receptor-γ–coactivator 1α (PGC-1α) gene expression in chronic kidney disease patients on hemodialysis: relation to hemodialysis-related cardiovascular morbidity and mortality

Cited by 6 publications

References 46 publications

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Novel role of COX6c in the regulation of oxidative phosphorylation and diseases

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