2013
DOI: 10.18632/aging.100519
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Abstract: We studied the role of peroxisomal catalase in chronological aging of the yeastHansenula polymorpha in relation to various growth substrates. Catalase-deficient (cat) cells showed a similar chronological life span (CLS) relative to the wild-type control upon growth on carbon and nitrogen sources that are not oxidized by peroxisomal enzymes. However, when media contained methylamine, which is oxidized by peroxisomal amine oxidase, the CLS of cat cells was significantly reduced. Conversely, the CLS of cat cells … Show more

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Cited by 21 publications
(14 citation statements)
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References 57 publications
(59 reference statements)
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“…Since the β -oxidation pathway directly produces H 2 O 2 , the detoxifying catalase activity is of central importance for the redox balance of the organelle [ 16 , 17 ]. It has been shown in yeast that peroxisomal catalase is required also for the tolerance to externally added H 2 O 2 , which suggests that peroxisomes are generally important for cellular ROS detoxification [ 18 ]. An additional peroxisomal antioxidant activity has been described in yeast as the glutathione peroxidase Gpx1, whose activity is generally required for a proper peroxisomal biogenesis [ 19 ].…”
Section: Pro- and Antioxidant Functions Of Peroxisomesmentioning
confidence: 99%
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“…Since the β -oxidation pathway directly produces H 2 O 2 , the detoxifying catalase activity is of central importance for the redox balance of the organelle [ 16 , 17 ]. It has been shown in yeast that peroxisomal catalase is required also for the tolerance to externally added H 2 O 2 , which suggests that peroxisomes are generally important for cellular ROS detoxification [ 18 ]. An additional peroxisomal antioxidant activity has been described in yeast as the glutathione peroxidase Gpx1, whose activity is generally required for a proper peroxisomal biogenesis [ 19 ].…”
Section: Pro- and Antioxidant Functions Of Peroxisomesmentioning
confidence: 99%
“…Moreover, catalase mutants show phenotypes of accelerated aging in the Caenorhabditis model [ 27 ]. In yeast, loss of catalase function modulates the lifespan depending on the metabolic activity of peroxisomes [ 18 ]. Thus, peroxisomal (together with mitochondrial) activity in maintaining the cellular redox state is generally important for cell survival and health [ 28 , 29 ].…”
Section: Pro- and Antioxidant Functions Of Peroxisomesmentioning
confidence: 99%
“…Among them are the following "downstream" processes (Figure 2): (1) the maintenance of trehalose homeostasis, a longevity-defining process known to modulate proteostasis in chronologically "young" and "old" cells 2361 (Figure 1A); (2) the maintenance of the homeostasis of glycogen, a reserve carbohydrate whose elevated level in chronologically "young" and "old" cells is a hallmark of carbohydrate metabolism remodeling in yeast cultured under CR 23; (3) the maintenance of the homeostasis of neutral lipids deposited within LD, a process known to play an essential role in regulating longevity of chronologically aging yeast 142392 (Figure 1B); (4) peroxisomal oxidation of fatty acids, a process implicated in yeast chronological aging 14239192 (Figure 1B); (5) the maintenance of the homeostasis of non-esterified ("free") fatty acids and diacylglycerol, whose reduced levels in chronologically "young" and "old" cells are characteristic of lipid metabolism remodeling in yeast cultured under CR - a pattern likely linked to the demonstrated abilities of both lipid species to elicit an age-related form of liponecrotic PCD 1423103 (Figure 1B); (6) the maintenance of a balance between the relative rates of glycolysis and gluconeogenesis, a process known to impact the level of ethanol in chronologically "young" and "old" yeast - thus defining the extent to which this product of glucose fermentation suppresses the longevity-extending process of peroxisomal oxidation of fatty acids 1423 (Figure 1B); (7) the longevity-extending process of mitochondrial translation 23505156; (8) the maintenance of a balance between the relative rates of mitochondrial fusion and fission, a process known to define the size and number of mitochondria, the length of mitochondrial cristae extending from the IMM, and the level of ATP synthesized in mitochondria of chronologically "young" and "old" yeast 14236470; (9) the development of an age-related pattern of susceptibility to chronic oxidative, thermal and osmotic stresses 314233350565962; (10) an age-related form of apoptotic PCD, which in chronologically "young" yeast is manifested in such early hallmark events of this PCD as the fragmentation of a tubular mitochondrial network into individual mitochondria, release of cytochrome c from mitochondria into the cytosol and phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane 1423 (Figure 1B); and (11) the development of a pattern of cell susceptibility to an age-related forms of apoptotic and liponecrotic PCD elicited by an exposure to exogenous hydrogen peroxide or palmitoleic acid, respectively 142359103.…”
Section: Cell-autonomous Mechanisms Orchestrate Longevity-defining Cementioning
confidence: 99%
“…The initial data on the role of peroxisomal catalase suggested that the absence of catalase decreases the lifespan of cells (Petriv & Rachubinski, 2004 ; Koepke et al ., 2007 , 2008 ). Recent studies however indicate that the absence of catalase also can extend the lifespan of cells at conditions that peroxisomal ROS activate anti-aging enzymes (Mesquita et al ., 2010 ; Titorenko & Terlecky, 2011 ; Kawałek et al ., 2013 ).…”
Section: Introductionmentioning
confidence: 99%