volume 53, issue 3, P335-347 2009
DOI: 10.1111/j.1755-3768.1975.tb01165.x
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ASBJØRN M. TØNJUM

Abstract: A tight barrier against permeation of horseradish peroxidase into the corneal epithelium exists at the corneal surface adjacent to the tear film. The present light and transmission electron microscopic study reveals that the cationic surfactant, benzalkonium chloride, which is commonly added to eye drops as a preservative, breaks down this barrier. Lysis of the cell membranes was demonstrated, resulting in a leakage of the tracer into and underneath the superficial cells. The grade of cellular destruction caus…

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