Perme Intensive Care Unit Mobility Score: Analysis of mobility improvement in critical care patients admitted to a university hospital in Brazil

Deponti, Gracieli Nadalon; Naue, Wagner da Silva; Hervé, Bruno Barcellos; Piekala, Daniele Martins; Glaeser, Sheila Suzana; Martins, Luciane de Fraga Gomes; Dias, Alexandre Simões

doi:10.1016/j.jcrc.2017.09.091

Cited by 2 publications

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“…Chloroquine and hydroxychloroquine are known drugs that interfere with SARS-CoV-2 cellular entry by inhibiting glycosylation and elevating endosomal pH but had suffered controversies for the treatment of COVID-19 infection; however, they were previously used for the prevention and treatment of malaria [ 112 , 118 , 119 ]. Chloroquine could practically inhibit SARS-CoV-2 through its immunomodulatory activity and evidence of reducing viral replication [ 118 , 120 , 121 ]. Likewise, a combination of azithromycin and hydroxychloroquine was discovered to possess a significant synergetic effect to decrease viral load and early recuperation [ 122 ].…”

Section: Treatment Of Human Coronavirusesmentioning

confidence: 99%

An Overview of the Pathogenesis, Transmission, Diagnosis, and Management of Endemic Human Coronaviruses: A Reflection on the Past and Present Episodes and Possible Future Outbreaks

et al. 2021

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The outbreak of the 2019 coronavirus pandemic caught the world by surprise in late 2019 and has held it hostage for months with an increasing number of infections and deaths. Although coronavirus was first discovered in the 1960s and was known to cause respiratory infection in humans, no information was available about the epidemic pattern of the virus until the past two decades. This review addresses the pathogenesis, transmission dynamics, diagnosis, management strategies, the pattern of the past and present events, and the possibility of future outbreaks of the endemic human coronaviruses. Several studies have described bats as presumptive natural reservoirs of coronaviruses. In essence, the identification of a diverse group of similar SARS coronaviruses in bats suggests the possibility of a future epidemic due to severe acute respiratory syndrome (SARS-like) coronaviruses originating from different reservoir hosts. The study also identified a lack of vaccines to prevent human coronavirus infections in humans in the past, however, the recent breakthrough in vaccine discovery and approval for emergency use for the treatment of Severe Acute Respiratory Syndrome Coronavirus 2 is commendable. The high rates of genomic substitution and recombination due to errors in RNA replication and the potential for independent species crossing suggest the chances of an entirely new strain evolving. Therefore, rapid research efforts should be deployed for vaccination to combat the COVID-19 pandemic and prevent a possible future outbreak. More sensitization and enlightenment on the need to adopt good personal hygiene practices, social distancing, and scientific evaluation of existing medications with promising antiviral effects against SARS-CoV-2 is required. In addition, intensive investigations to unravel and validate the possible reservoirs, the intermediate host, as well as insight into the ability of the virus to break the species barrier are needed to prevent future viral spillover and possible outbreaks.

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Section: Treatment Of Human Coronavirusesmentioning

confidence: 99%

An Overview of the Pathogenesis, Transmission, Diagnosis, and Management of Endemic Human Coronaviruses: A Reflection on the Past and Present Episodes and Possible Future Outbreaks

et al. 2021

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Overview of Covid-19; its prevention and management in the light of Unani medicine

Nikhat

Fazil

2020

Science of The Total Environment

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Journal Pre-proof J o u r n a l P r e -p r o o f ABSTRACT Since December 2019, a respiratory pandemic, named as Coronavirus disease 2019 (Covid-19)caused by a new coronavirus named as SARS-CoV-2, has taken the world by storm. The symptoms are fever, malaise, and cough which resolve in a few days in most cases; but may progress to respiratory distress and organ failure. Transmission is through droplet infection or fomites, but other modes such as airborne transmission and oro-fecal transmission is also speculated. Research is underway to develop effective vaccines and medicines for the disease. In such a scenario, we present the measures described in Unani system of medicine for health protection during epidemics. Unani is a traditional system of medicine developed during the middle ages, which employs natural drugs of herbal, animal and mineral origin for treatment. In Unani medicine, during an epidemic, apart from isolation and quarantine, three measures are of utmost importance, (i) purification of surroundings using certain herbal drugs as fumigants or sprays, (ii) health promotion and immune-modulation, and (iii) use of health-protecting drugs and symptom-specific drugs. Drugs such as loban (Styrax benzoides W. G. Craib), sandroos (Hymenaea verrucosa Gaertn.) za'fran (Crocus sativus L.), vinegar etc. are prescribed in various forms. Scientific researches on these drugs reveal the presence of a number of pharmacologically active substances, which may provide a new insight into the management of infections and epidemics. Journal Pre-proof J o u r n a l P r e -p r o o f ABBREVIATIONS

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Perme Intensive Care Unit Mobility Score: Analysis of mobility improvement in critical care patients admitted to a university hospital in Brazil

Cited by 2 publications

References 0 publications

An Overview of the Pathogenesis, Transmission, Diagnosis, and Management of Endemic Human Coronaviruses: A Reflection on the Past and Present Episodes and Possible Future Outbreaks

An Overview of the Pathogenesis, Transmission, Diagnosis, and Management of Endemic Human Coronaviruses: A Reflection on the Past and Present Episodes and Possible Future Outbreaks

Overview of Covid-19; its prevention and management in the light of Unani medicine

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