1999
DOI: 10.1046/j.1525-1594.1999.06355.x
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Abstract: This paper looks at the prospects for new surgical solutions to the problem of end-stage heart failure based on cardiac assistance from skeletal muscle. The current status of the main biological approaches, cardiomyoplasty, aortomyoplasty, and the skeletal muscle ventricle, are discussed, followed by a consideration of some of the important basic issues that need to be addressed if these techniques are to achieve their full potential. Although there is a review element to the paper, the main emphasis is on the… Show more

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Cited by 15 publications
(4 citation statements)
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“…A third area includes applications in which the muscle is partially mobilized and redeployed to perform a different function. For example, a pedicle graft of the latissimus dorsi muscle can be transferred into the chest to assist a failing heart (40). This is achieved either by wrapping it around existing structures, the ventricles of the heart in cardiomyoplasty (14), and the ascending or descending aorta in aortomyoplasty (48), or by forming it into an auxiliary pump or skeletal muscle ventricle (1,47).…”
mentioning
confidence: 99%
“…A third area includes applications in which the muscle is partially mobilized and redeployed to perform a different function. For example, a pedicle graft of the latissimus dorsi muscle can be transferred into the chest to assist a failing heart (40). This is achieved either by wrapping it around existing structures, the ventricles of the heart in cardiomyoplasty (14), and the ascending or descending aorta in aortomyoplasty (48), or by forming it into an auxiliary pump or skeletal muscle ventricle (1,47).…”
mentioning
confidence: 99%
“…Thus far, only dynamic cardiomyoplasty and dynamic aortomyoplasty have been introduced into clinical practice. Although the protocol widely used for cardiomyoplasty is far from ideal (6,7), follow‐up studies show that 80% of the patients experience symptomatic improvement. It has, however, been difficult to demonstrate any consistent hemodynamic change (8).…”
Section: Discussionmentioning
confidence: 99%
“…The resultant muscle has a '2A' phenotype, with the necessary fatigue resistance allied to fast contractile characteristics. We have argued for many years that this should be the proper goal of conditioning for cardiac assistance [45][46][47][48][49].…”
Section: Fast Fatigue-resistant Musclementioning
confidence: 99%