Periventricular hyperintensity as seen by magnetic resonance: prevalence and significance

Zimmerman, Robert D.; Fleming, Cynthia A.; Lee, Benjamin C. P.; Saint-Louis, Leslie A.; Deck, Michael D. F.

doi:10.2214/ajr.146.3.443

Cited by 173 publications

(66 citation statements)

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“…There was, however, a significant number (7/42=17%, 95% CI 7-31%) of negative correlations between changes in periventricular white matter40 and SPECT measures across all patients—that is, perfusion in the caudate, parietal, and left anterior temporal cortex including ROI 3 and right thalamus.…”

Section: Resultsmentioning

confidence: 90%

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Temporal lobe abnormalities in dementia and depression: a study using high resolution single photon emission tomography and magnetic resonance imaging

Ebmeier

Prentice

Ryman

et al. 1997

Journal of Neurology, Neurosurgery & Psychiatry

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Objectives-Perfusion SPECT and MRI were used to test the hypothesis that late onset depression is associated with brain abnormalities. Tcexametazime (HM-PAO). Temporal lobe templates were fitted with brains pitched by 20°-30°. A subgroup of 41 patients (22 depressed) were also scanned using a Siemens Magnetron 1.0 Tesla magnetic resonance imager, using a FLAIR imaging sequence for the assessment of white matter hyperintensities, and a Turbo FLASH sequence for the measurement of medial temporal lobe width. Results-Demented patients showed reduced perfusion, particularly in the left temporoparietal cortex. In these regions of interest, patients with late onset depression tended to have perfusion values intermediate between patients with early onset depression and demented patients. DiVerences in changes in white matter between demented and early and late onset depressive patients did not reach conventional levels of significance. Temporal lobe width diVered between demented and depressed patients, but not between early and late onset depressed patients. Perfusion and temporal lobe width were not associated, but reductions of perfusion were associated with periventricular white matter changes. Mini mental state examination scores were associated with temporal perfusion in demented patients and with changes in deep white matter in depressed patients. Finally, severity of depressive symptoms was associated with decreased perfusion in frontotemporal and basal ganglia regions of interest. Methods-FortyConclusion-A cumulative eVect of duration of illness on regional cerebral perfusion could not be confirmed. Late onset depression may show more abnormalities of deep white matter and of left temporoparietal perfusion than early onset depression, but the underlying pathology remains to be established.

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Section: Resultsmentioning

confidence: 90%

“…As this produces fixed shifts, a selection of programmes with different values was written. FLAIR images were examined by an experienced radiologist (JKKB) and scored for periventricular and deep white matter hyperintensities using the methods proposed by Zimmerman et al 40 and Meguro et al 41…”

Section: Methodsmentioning

confidence: 99%

Temporal lobe abnormalities in dementia and depression: a study using high resolution single photon emission tomography and magnetic resonance imaging

Ebmeier

Prentice

Ryman

et al. 1997

Journal of Neurology, Neurosurgery & Psychiatry

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“…Since no differences were revealed between the groups of complete and incomplete CoW regarding the LA confounders, such as mean age, gender ratio, hypertension, diabetes mellitus, hypercholesterolemia, and coronary artery disease [1,2,3] (table 1), we believe that CoW anatomy is an independent contributor to LA in case of carotid artery stenosis [13,14,15,16]. …”

Section: Discussionmentioning

confidence: 99%

“…These incidental hyperintensities, labeled as white matter lesion (WML) or LA, are frequently identified in the periventricular region as periventricular hyperintensity (PVH) and/or in the deep subcortical region as deep white matter lesion (DWML) [2]. Independent risk factors for LA are hypertension, aging, and increased carotid artery stenosis.…”

Section: Background and Purposementioning

confidence: 99%

Associations between Circle of Willis Morphology and White Matter Lesion Load in Subjects with Carotid Artery Stenosis

et al. 2011

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Background: Various cerebral pathological changes have been reported to cause leukoaraiosis (LA). We hypothesized that circle of Willis (CoW) anomalies may contribute to LA in severe carotid artery stenosis victims through impaired cerebral autoregulation. We conducted a retrospective review on cerebral magnetic resonance (MR) patterns in patients with severe symptomatic carotid artery stenosis and compared white matter lesion (WML) load between subjects with and without complete CoW. Methods: LA on fluid attenuation inversion recovery (FLAIR) MR images at the levels of the centrum semiovale and frontal horns in both cerebral hemispheres were scored in 106 patients with unilateral carotid artery stenosis (64 men and 42 women; mean age 68.7 ± 9.2 years, range 44–82). Subjects were divided into groups of complete and incomplete CoW according to cerebral MR angiography. Differences in the LA scores between the groups of complete and incomplete CoW were further analyzed. Results: Compared with those with incomplete configuration of the CoW, subjects with a complete CoW demonstrated a decreased WML load at the level of the centrum semiovale (2.78 ± 1.17 vs. 5.62 ± 2.12, p = 0.02) and frontal horns (2.21 ± 0.79 vs. 4.22 ± 1.83, p = 0.01). Conclusion: Our results support the importance of a complete CoW since it may protect from WML in case of carotid stenosis.

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“…20 Results of MR imaging have demonstrated that white matter abnormalities are frequent in normal aging and in various types of dementia. 103 The presence of multiple lacunar infarcts may indicate a diagnosis of multiinfarct dementia. Nevertheless, cerebrovascular disease has been increasingly associated with NPH.…”

Section: Periventricular Lucencies In Patients With Nph: Are They Alwmentioning

confidence: 99%

Is the placement of shunts in patients with idiopathic normal pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure

Poca¹,

Mataró²,

Matarín³

et al. 2004

Journal of Neurosurgery

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Periventricular hyperintensity as seen by magnetic resonance: prevalence and significance

Cited by 173 publications

References 0 publications

Temporal lobe abnormalities in dementia and depression: a study using high resolution single photon emission tomography and magnetic resonance imaging

Temporal lobe abnormalities in dementia and depression: a study using high resolution single photon emission tomography and magnetic resonance imaging

Associations between Circle of Willis Morphology and White Matter Lesion Load in Subjects with Carotid Artery Stenosis

Is the placement of shunts in patients with idiopathic normal pressure hydrocephalus worth the risk? Results of a study based on continuous monitoring of intracranial pressure

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