“…PEComas are immunoreactive for at least one melanocytic marker (HMB-45, melan-A, tyrosinase, and MiTF) and one smooth muscle marker (smooth muscle actin, pan-muscle actin, desmin, h-caldesmon, calponin, and muscle myosin). [ 2 , 10 ] Leiomyosarcoma shows positivity only for smooth muscle markers. Pan-cytokeratin and epithelial membrane antigen help in distinguishing between a metastatic carcinoma and PEComa, being positive in carcinoma.…”