1979
DOI: 10.1001/archderm.115.3.300
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Periumbilical perforating pseudoxanthoma elasticum

Abstract: Periumbilical pseudoxanthoma elasticum (PXE) with transepidermal elimination of altered elastica presented a distinctive clinical pattern in six middle-aged, multiparous women. Other sites usually affected in PXE were spared. The possible genetic predisposition to PXE of these patients found its expression in the periumbilical skin, a site exposed to the trauma of multiple pregnancies. The extruded elastica had tinctorial properties that were characteristic of PXE. The clinical picture in our cases differs fro… Show more

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Cited by 16 publications
(14 citation statements)
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“…84,86,87 Almost twice as many cases of the perforating subtype have been reported; of these, most occurred in obese, multiparous, black women in the fifth or sixth decade of life, although occurrence in white women has also been reported. [88][89][90] Etiology and pathogenesis. Farmers with a history of exposure to Norwegian saltpeter (calciumammonium-nitrate salts) fertilizer may be at risk for the development of acquired PXE.…”
Section: Elastosis Perforans Serpiginosamentioning
confidence: 99%
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“…84,86,87 Almost twice as many cases of the perforating subtype have been reported; of these, most occurred in obese, multiparous, black women in the fifth or sixth decade of life, although occurrence in white women has also been reported. [88][89][90] Etiology and pathogenesis. Farmers with a history of exposure to Norwegian saltpeter (calciumammonium-nitrate salts) fertilizer may be at risk for the development of acquired PXE.…”
Section: Elastosis Perforans Serpiginosamentioning
confidence: 99%
“…84,87,91 The perforating subtype of acquired PXE has been reported predominantly in the periumbilical area of multiparous women and in patients with severe ascites or a history of abdominal surgery, which suggests that mechanical stress may be important in the pathogenesis. 89,[92][93][94] It has also been reported in patients with dialysis-dependent chronic renal failure, suggesting that abnormal calciumphosphate metabolism leading to hyperphosphatemia may be a risk factor, although this hypothesis has not been systematically studied. 95 Clinical manifestations.…”
Section: Elastosis Perforans Serpiginosamentioning
confidence: 99%
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“…Posttraumatic, localized, cutaneous lesions, lacking the retinal and vascular stigmata of the inherited type, have been reported in a number of cases. [51][52][53] In contrast, the potentially acquired nature of a PXE syndrome encountered in a couple of cases with chronic renal failure is strongly questioned by some investigators. 1,54,55 In ␤ thalassemia and SCD, it is believed that the elastic tissue abnormalities are most likely acquired, despite their clinical, structural, and cytochemical resemblance to inherited PXE.…”
Section: Pathogenesis and Geneticsmentioning
confidence: 99%